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Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion
Mariyamma, Neema Prabhakaran1; Hou, Hongwei1,3; Carland, Francine M.2; Nelson, Timothy2; Schultz, Elizabeth A.1
Corresponding AuthorSchultz, Elizabeth A.(schultz@uleth.ca)
2017-06-15
Source PublicationJOURNAL OF EXPERIMENTAL BOTANY
ISSN0022-0957
Volume68Issue:13Pages:3375-3390
AbstractWhen FORKED1 (FKD1) is mutated, asymmetric localization of PINFORMED1 (PIN1), particularly to the apical side of cells, fails to occur properly in developing veins, resulting in an open vein pattern. FKD1 encodes a protein with a Pleckstrin homology-like (PL) domain, suggesting interaction with phosphoinositides. FKD1 has been previously found to interact with an ADP ribosylation factor GTPase-activating protein (ARF-GAP) important for vein patterning, SCARFACE/VAN3 (SFC). We find that FKD1-green fluorescent protein (GFP) localizes to the plasma membrane and to punctae labeled by SFC-yellow fluorescent protein (YFP). Supporting the idea that the FKD1 PL domain recognizes phosphatidylinositol 4-phosphate [PtdIns(4)P], FKD1-GFP co-localizes with PtdIns(4) P markers, and is more cytosolic when in a background mutant for the PtdIns(4,5)P-2 hydrolases CVP2 and CVL1. Both FKD1 and SFC partially co-localize with markers for the trans-Golgi network (TGN), at which endocytic and secretory pathways merge. FKD1-labeled punctae rarely co-localize with the endocytic marker FM4-64, suggesting that FKD1 is not involved primarily in the endocytic pathway. FKD1 and SFC co-localize with members of the RABA group of RAB-GTPases, which are proposed to act in the post-Golgi secretory pathway. The compartments labeled by FKD1 and SFC do not localize to membrane compartments induced by the fungal toxin brefeldin A (BFA). Collectively, our data suggest that FKD1 and SFC act in a BFA-insensitive secretory pathway.
KeywordFORKED1 leaf vein patterning PIN1 localization RABA SCARFACE/VAN3 secretory pathway vascular differentiation
DOI10.1093/jxb/erx180
Funding OrganizationNatural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship
Indexed BySCI ; SCI
Language英语
Funding ProjectNatural Science and Engineering Research Council ; National Science Foundation[IOS-0718881] ; National Science Foundation[IBN-416731] ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000408119100009
WOS KeywordTRANS-GOLGI NETWORK ; ROOT HAIR-CELLS ; GNOM ARF-GEF ; MEMBRANE TRAFFICKING ; PLASMA-MEMBRANE ; ENDOPLASMIC-RETICULUM ; AUXIN TRANSPORTERS ; PATTERN-FORMATION ; LEAF VENATION ; MARKER SET
PublisherOXFORD UNIV PRESS
Funding OrganizationNatural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; Natural Science and Engineering Research Council ; National Science Foundation ; National Science Foundation ; National Science Foundation ; National Science Foundation ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Ingenuity Post-doctoral Fellowship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship ; Alberta Innovates Technology Futures Graduate Scholarship
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31386
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorSchultz, Elizabeth A.
Affiliation1.Univ Lethbridge, Dept Biol Sci, Lethbridge, AB TIK 3M4, Canada
2.Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Mariyamma, Neema Prabhakaran,Hou, Hongwei,Carland, Francine M.,et al. Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion[J]. JOURNAL OF EXPERIMENTAL BOTANY,2017,68(13):3375-3390.
APA Mariyamma, Neema Prabhakaran,Hou, Hongwei,Carland, Francine M.,Nelson, Timothy,&Schultz, Elizabeth A..(2017).Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion.JOURNAL OF EXPERIMENTAL BOTANY,68(13),3375-3390.
MLA Mariyamma, Neema Prabhakaran,et al."Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion".JOURNAL OF EXPERIMENTAL BOTANY 68.13(2017):3375-3390.
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