Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription | |
Wu, Min1,2; Dan, Cheng1; Gui, Jian-Fang1,2,3; Zhang, Yi-Bing1,2,3,4 | |
2019-07-01 | |
Source Publication | FISH & SHELLFISH IMMUNOLOGY
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ISSN | 1050-4648 |
Volume | 90Issue:1Pages:180-187 |
Abstract | In mammals and fish, emerging evidence highlights that TRIM family members play important roles in the interferon (IFN) antiviral immune response. Fish TRIM family has undergone an unprecedented expansion leading to generation of finTRIM subfamily, which is exclusively specific to fish. Our recent results have shown that FTRCA1 (finTRIM C. auratus 1) is likely a fish species-specific finTRIM member in crucian carp C. auratus and acts as a negative modulator to downregulate fish IFN response by autophage-lysosomal degradation of protein kinase TBK1. In the present study, we found that FTRCA1 also impedes the activation of crucian carp IFN promoter by IRF7 but not by IRF3. Mechanistically, FTRCA1 attenuates IRF7 transcription levels likely due to enhanced decay of IRF7 mRNA, leading to reduced IRF7 protein levels and subsequently reduced fish IFN expression. E3 ligase activity is required for FTRCA1 to negatively regulate IRF7-mediated IFN response, because ligase-inactive mutants and the RING-deleted mutant of FTRCA1 lose the ability to block the activation of crucian carp IFN promoter by IRF7. These results together indicate that FTRCA1 is a multifaceted modulator to target different signaling factors for shaping fish IFN response in crucian carp. |
Keyword | finTRIM FTRCA1 RLR signaling IFN antiviral response Negative regulation |
DOI | 10.1016/j.fsi.2019.04.297 |
Funding Organization | National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; 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Indexed By | SCI |
Language | 英语 |
Funding Project | National Key R&D Program of China[2018YFD0900302] ; National Natural Science Foundation of China[31572646] ; National Natural Science Foundation of China[31772875] ; Freshwater Ecology and Biotechnology Laboratory[2019FBZ04] |
WOS Research Area | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS Subject | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS ID | WOS:000471085000020 |
WOS Keyword | ANTIVIRAL RESPONSE ; RIG-I ; ZEBRAFISH IRF1 ; PROTEINS ; FAMILY ; ROLES ; ACTIVATION ; EXPRESSION ; IFN-PHI-1 ; REVEALS |
Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
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Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/31336 |
Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
Corresponding Author | Zhang, Yi-Bing |
Affiliation | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Hubei, Peoples R China 4.Chinese Acad Sci, Key Lab Aquaculture Dis Control, Minist Agr, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
Recommended Citation GB/T 7714 | Wu, Min,Dan, Cheng,Gui, Jian-Fang,et al. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription[J]. FISH & SHELLFISH IMMUNOLOGY,2019,90(1):180-187. |
APA | Wu, Min,Dan, Cheng,Gui, Jian-Fang,&Zhang, Yi-Bing.(2019).Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription.FISH & SHELLFISH IMMUNOLOGY,90(1),180-187. |
MLA | Wu, Min,et al."Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription".FISH & SHELLFISH IMMUNOLOGY 90.1(2019):180-187. |
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