IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species
Khan, Suliman1,2,3; Ullah, Muhammad Wajid4; Siddique, Rabeea1,4; Liu, Yang1,5; Ullah, Ismat6; Xue, Mengzhou1,5; Yang, Guang4; Hou, Hongwei2,3
2019-06-13
Source PublicationFRONTIERS IN ONCOLOGY
ISSN2234-943X
Volume9Issue:1Pages:13
Abstract

Osteosarcoma is the most common bone cancer with limited therapeutic options. It can be treated by selenium-doped hydroxyapatite owing to its known antitumor potential. However, a high concentration of Se is toxic toward normal and stem cells whereas its low concentration cannot effectively remove cancer cells. Therefore, the current study was aimed to improve the anticancer activity of Se-HAp nanoparticles through catechins (CC) modification owing to their high cancer therapeutic value. The sequentially developed catechins modified Se-HAp nanocomposites (CC/Se-HAp) were characterized for various physico-chemical properties and antitumor activity. Structural analysis showed the synthesis of small rod-like single phase HAp nanoparticles (60 +/- 15 nm), which effectively interacted with Se and catechins and formed agglomerated structures. TEM analysis showed the internalization and degradation of CC/Se-HAp nanomaterials within MNNG/HOS cells through a non-specific endocytosis process. Cell toxicity analysis showed that catechins modification improved the antitumor activity of Se-HAp nanocomposites by inducing apoptosis of human osteosarcoma MNNG/HOS cell lines, through generation of reactive oxygen species (ROS) which in turn activated the caspase-3 pathway, without significantly affecting the growth of human normal bone marrow stem cells (hBMSCs). qPCR and western blot analyses revealed that casp3, p53, and bax genes were significantly upregulated while cox-2 and PTK-2 were slightly downregulated as compared to control in CC/Se-HAp-treated MNNG/HOS cell lines. The current study of combining natural biomaterial (i.e., catechins) with Se and HAp, can prove to be an effective therapeutic approach for bone cancer therapy.

Keywordosteosarcoma catechins selenium hydroxyapatite ROS cancer therapy
DOI10.3389/fonc.2019.00499
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
Indexed BySCI
Language英语
Funding ProjectNational Science Foundation of China[31870917] ; National Science Foundation of China[81471174] ; National Science Foundation of China[81520108011] ; National Science Foundation of China[81870942] ; National Key Research and Development Program of China[2018YFC1312200] ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation[2016M602291]
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000471845900001
WOS KeywordGREEN TEA ; LUNG METASTASES ; CANCER CELLS ; NANOPARTICLES ; SIZE ; INHIBITION ; APOPTOSIS ; SURVIVAL ; DESIGN ; GROWTH
PublisherFRONTIERS MEDIA SA
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; 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Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31314
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorXue, Mengzhou; Yang, Guang; Hou, Hongwei
Affiliation1.Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China
2.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan, Hubei, Peoples R China
5.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China
6.Huazhong Univ Sci & Technol, State Key Lab Mat Proc & Die Mold Technol, Sch Mat Sci & Engn, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Khan, Suliman,Ullah, Muhammad Wajid,Siddique, Rabeea,et al. Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species[J]. FRONTIERS IN ONCOLOGY,2019,9(1):13.
APA Khan, Suliman.,Ullah, Muhammad Wajid.,Siddique, Rabeea.,Liu, Yang.,Ullah, Ismat.,...&Hou, Hongwei.(2019).Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species.FRONTIERS IN ONCOLOGY,9(1),13.
MLA Khan, Suliman,et al."Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species".FRONTIERS IN ONCOLOGY 9.1(2019):13.
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