IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus)
Ou, Mi1; Huang, Rong2; Luo, Qing1; Xiong, Lv2; Chen, Kunci1; Wang, Yaping2
2019-06-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume89Issue:1Pages:614-622
Abstract

Scavenger receptor class B type 1 (SRB1) is a transmembrane protein belonging to the scavenger receptors (SRs) family and it plays an important role in viral entry. Not much is known on SRB1 in teleost fish. Grass carp reovirus (GCRV) cause huge economic losses in grass carp industry. In this study, rare minnow (Gobiocypris rarus) was used as a model fish to investigate the mechanism of GCRV infection, which is sensitive to GCRV. The structure of SRB1 gene in G. rarus (GrSRB1) was cloned and elucidated. GrSRB1 is composed of 13 exons and 12 introns, and its full-length cDNA is 2296 bp in length, with 1521 bp open reading frame (ORF) that encodes a 506 amino acid protein. The GrSRB1 protein is predicted to contain a typical CD36 domain and two transmembrane regions. In G. rarus, GrSRB1 is expressed strongly in the liver (L), intestines (I), brain (B) and muscle (M), while it is expressed poorly in the heart (H), middle kidney (MK), head kidney (HK) and gills (G). After infection with GCRV, GrSRB1 expression was up-regulated in main immune tissues during the early infection period. Moreover, co-immunoprecipitation assays revealed that GrSRB1 could interact with the outer capsid protein of GCRV (VP5 and VP7). These results suggest that GrSRB1 could be a receptor for GCRV. We have managed to characterize the GrSRB1 gene and provide evidence for its potential functions for GCRV entry into host cells.

KeywordRare minnow GCRV SRB1 Receptor Cell entry
DOI10.1016/j.fsi.2019.04.031
Funding OrganizationCentral Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System
Indexed BySCI
Language英语
Funding ProjectCentral Public-interest Scientific Institution Basal Research Fund, CAFS[2018HY-XKQ02-06] ; National Natural Science Foundation of China[31572614] ; China Agricultural Research System[CARS-46]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000469897700068
WOS KeywordHEPATITIS-C VIRUS ; SR-BI ; ENHANCING PHAGOCYTOSIS ; MOLECULAR-CLONING ; EXPRESSION ; IDENTIFICATION ; PROTECTS ; BACTERIA ; PATHWAY ; PROLIFERATION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationCentral Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/31255
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorChen, Kunci; Wang, Yaping
Affiliation1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Trop & Subtrop Fishery Resources Applicat, Guangzhou 510380, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Ou, Mi,Huang, Rong,Luo, Qing,et al. Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus)[J]. FISH & SHELLFISH IMMUNOLOGY,2019,89(1):614-622.
APA Ou, Mi,Huang, Rong,Luo, Qing,Xiong, Lv,Chen, Kunci,&Wang, Yaping.(2019).Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus).FISH & SHELLFISH IMMUNOLOGY,89(1),614-622.
MLA Ou, Mi,et al."Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus)".FISH & SHELLFISH IMMUNOLOGY 89.1(2019):614-622.
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