IHB OpenIR  > 藻类生物学及应用研究中心  > 期刊论文
Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV
Cheng, Yong1,2,3; Schorey, Jeffrey S.1,2,3; Zhang, Cheng-Cai5; Tan, Xuejuan1,4
Corresponding AuthorCheng, Yong(ycheng5@nd.edu)
2017
Source PublicationCURRENT PHARMACEUTICAL DESIGN
ISSN1381-6128
Volume23Issue:29Pages:4369-4389
AbstractInfectious diseases that are caused by pathogenic microbes such as bacteria, viruses, parasites or fungi remain the top major cause of death across the world, particularly in low income countries, and may be transmitted from person to person, or from insects or animals. In general, infectious diseases may be treated with antimicrobial agents including antibiotics, antiviral, antifungal or antiparasitic medications. The therapeutic application of antimicrobial drugs in the 20th century substantially contributed to the global control of infectious diseases worldwide. However, pathogenic microbes have evolved various mechanisms to render the antimicrobial drugs less effective. This has resulted in an increasing number of people infected with pathogenic microbes that are resistant to antimicrobial drugs, and in some cases leading to untreatable infections. Therefore, new antimicrobial drugs are urgently needed to prevent possible recurrence and emergence of previously treatable infectious diseases. In the past decades, protein kinase inhibitors have become an attractive area in the development of novel antimicrobial drugs. In the current review, we will describe the recent efforts in the development of microbial and host protein kinase-targeting inhibitors as potential antimicrobial drugs against HIV, tuberculosis and malaria.
KeywordProtein kinase inhibitors antimicrobial drugs infectious diseases tuberculosis malaria AIDS
DOI10.2174/1381612823666170612122429
Indexed BySCI ; SCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000415378600013
WOS KeywordPARASITE PLASMODIUM-FALCIPARUM ; CYCLIN-DEPENDENT KINASES ; BRUTONS TYROSINE KINASE ; YEAST SCHIZOSACCHAROMYCES-POMBE ; 2-COMPONENT REGULATORY SYSTEM ; GLYCOGEN-SYNTHASE KINASE-3 ; SIGNAL-TRANSDUCTION SYSTEM ; HOST-DIRECTED THERAPIES ; CELL-DIVISION CYCLE ; DOUBLE-STRANDED-RNA
PublisherBENTHAM SCIENCE PUBL LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30742
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorCheng, Yong
Affiliation1.Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
2.Univ Notre Dame, Ctr Rare & Neglected Dis, Notre Dame, IN 46556 USA
3.Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
4.Univ Notre Dame, Harper Canc Res Inst, Notre Dame, IN 46556 USA
5.Chinese Acad Sci, Key Lab Algal Biol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Yong,Schorey, Jeffrey S.,Zhang, Cheng-Cai,et al. Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV[J]. CURRENT PHARMACEUTICAL DESIGN,2017,23(29):4369-4389.
APA Cheng, Yong,Schorey, Jeffrey S.,Zhang, Cheng-Cai,&Tan, Xuejuan.(2017).Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV.CURRENT PHARMACEUTICAL DESIGN,23(29),4369-4389.
MLA Cheng, Yong,et al."Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV".CURRENT PHARMACEUTICAL DESIGN 23.29(2017):4369-4389.
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