IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection
Xiong, Lv1,2; He, Libo1; Luo, Lifei1,2; Li, Yongming1; Liao, Lanjie1; Huang, Rong1; Zhu, Zuoyan1; Wang, Yaping1
2018-04-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume19Issue:4Pages:14
Abstract

Grass carp reovirus (GCRV) causes huge economic loss to the grass carp cultivation industry but the mechanism remains largely unknown. In this study, we investigated the global and complement gene-specific DNA methylation in grass carp after GCRV infection aimed to uncover the mechanism underlying GCRV infection. The global DNA methylation level was increased after GCRV infection. Expression levels of enzymes involved in DNA methylation including DNA methyltransferase (DNMT), ten-eleven translocation proteins (TETs), and glycine N-methyltransferase (GNMT) were significantly altered after GCRV infection. In order to investigate the relationship between the gene expression level and DNA methylation level, two representative complement genes, complement component 3 (C3) and kininogen-1 (KNG1), were selected for further analysis. mRNA expression levels of the two genes were significantly increased at 5 and 7 days after GCRV infection, whereas the DNA methylation level at the 5 0 flanking regions of the two genes were down-regulated at the same time-points. Moreover, a negative correlation was detected between gene expression levels and DNA methylation levels of the two genes. Therefore, the current data revealed a global and complement gene-specific DNA methylation profile after GCRV infection. Our study would provide new insights into understanding the mechanism underlying GCRV infection.

Keywordgrass carp grass carp reovirus DNA methylation gene expression complement component 3 kininogen-1 negative correlation
DOI10.3390/ijms19041110
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31702332] ; Strategic Priority Research Programme of Chinese Academy of Sciences[XDA08030203] ; Hubei Natural Science Foundation of China[2015CFA007]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000434978700189
WOS KeywordMESSENGER-RNA EXPRESSION ; GLYCINE N-METHYLTRANSFERASE ; CTENOPHARYNGODON-IDELLA ; PROKARYOTIC EXPRESSION ; GENOME ; MECHANISM ; DISEASE ; PROTEIN ; EPIGENETICS ; RESISTANCE
PublisherMDPI
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Strategic Priority Research Programme of Chinese Academy of Sciences ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30664
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorHe, Libo; Wang, Yaping
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xiong, Lv,He, Libo,Luo, Lifei,et al. Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(4):14.
APA Xiong, Lv.,He, Libo.,Luo, Lifei.,Li, Yongming.,Liao, Lanjie.,...&Wang, Yaping.(2018).Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(4),14.
MLA Xiong, Lv,et al."Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.4(2018):14.
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