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Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish
Chen, Liang1,2; Wang, Yeke1,2; Giesy, John P.3,4; Chen, Feng1,2; Shi, Ting1,2; Chen, Jun1; Xie, Ping1,5
2018-10-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume241Issue:1Pages:540-548
Abstract

Frequencies and durations of blooms of cyanobacteria are increasing. Some cyanobacteria can produce cyanotoxins including microcystins (MCs). MCs are the most common toxic products of hazardous algal blooms (HABs), with the greatest potential for exposure and to cause toxicity. Recently, MCs have been shown to disrupt endocrine functions. In this study, for the first time, effects of MC-LR on the hypothalamic-pituitary-inter-renal (HPI) axis during early embryonic development (embryos/larvae) of zebrafish (Danio rerio), were investigated. Embryos/larvae of zebrafish were exposed to 1, 10, 100, or 30014 MC-LR/L during the period of 4-168 h post-fertilization (hpf). Exposure to 300 mu g MC-LR/L resulted in significantly greater concentrations of whole-body cortisol than those in controls. Expressions of genes along the HPI axis and mineralocorticoid receptor (MR-) and glucocorticoid receptor (GR-) centered gene networks were evaluated by use of quantitative real-time PCR Expression of mRNA for crh was significantly down-regulated by exposure to 300 mu g MC-LR/L, while expressions of crhbp, crhr1, and crhr2 were significantly up-regulated, relative to controls. MC-LR caused significantly lesser levels of mRNA for steroidogenic genes including hmgra, star, and cyp17, but expression of mRNA for hsd20b was significantly greater than that of controls. Treatment with MC-LR also altered profiles of transcription of MR- and GR-centered gene networks, which might result in multiple responses. Taken together, these results demonstrated that MC-LR affected the corticosteroid-endocrine system of larvae of zebrafish. This study provided valuable insights into molecular mechanisms behind potential toxicity and endocrine disruption of MCs. (C) 2018 Elsevier Ltd. All rights reserved.

KeywordHazardous algal blooms Cortisol Endocrine disruption Steroids Gene expression
DOI10.1016/j.envpol.2018.05.024
Funding OrganizationNational Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China ; 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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundations of China[31770555] ; Qinghai Provincial Natural Science Foundation[2018-ZJ-709] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ08] ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, China[GDT20143200016] ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program in Environmental Toxicology ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000440390800058
WOS KeywordENVIRONMENTALLY RELEVANT CONCENTRATIONS ; CARP CTENOPHARYNGODON-IDELLA ; CORTICOSTEROID STRESS AXIS ; DANIO-RERIO ; THYROID-HORMONES ; FEMALE ZEBRAFISH ; REPRODUCTIVE TOXICITY ; ENDOCRINE DISRUPTION ; WATERBORNE EXPOSURE ; CARASSIUS-AURATUS
PublisherELSEVIER SCI LTD
Funding OrganizationNational Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; Qinghai Provincial Natural Science Foundation ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; 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Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Canada Research Chair program in Environmental Toxicology ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; 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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30562
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, Ping
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
4.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
5.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810016, Qinghai, Peoples R China
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Chen, Liang,Wang, Yeke,Giesy, John P.,et al. Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish[J]. ENVIRONMENTAL POLLUTION,2018,241(1):540-548.
APA Chen, Liang.,Wang, Yeke.,Giesy, John P..,Chen, Feng.,Shi, Ting.,...&Xie, Ping.(2018).Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish.ENVIRONMENTAL POLLUTION,241(1),540-548.
MLA Chen, Liang,et al."Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish".ENVIRONMENTAL POLLUTION 241.1(2018):540-548.
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