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Genome-wide identification of 99 autophagy-related (Atg) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium
Kang, Hye-Min1; Lee, Jin-Sol1; Kim, Min-Sub1; Lee, Young Hwan1; Jung, Jee-Hyun2; Hagiwara, Atsushi3,4; Zhou, Bingsheng5; Lee, Jae-Seong1; Jeong, Chang-Bum1
2018-08-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume201Issue:1Pages:73-82
Abstract

Autophagy originated from the common ancestor of all life forms, and its function is highly conserved from yeast to humans. Autophagy plays a key role in various fundamental biological processes including defense, and has developed through serial interactions of multiple gene sets referred to as autophagy-related (Atg) genes. Despite their significance in metazoan life and evolution, few studies have been conducted to identify these genes in aquatic invertebrates. In this study, we identified whole Atg genes in four Brachionus rotifer spp., namely B. calycifiorus, B. koreanus, B. plicatilis, and B. rotundiformis, through searches of their entire genomes; and we annotated them according to the yeast nomenclature. Twenty-four genes orthologous to yeast genes were present in all of the Brachionus spp. while three additional gene duplicates were identified in the genome of B. koreanus, indicating that these genes had diversified during the speciation. Also, their transcriptional responses to cadmium exposure indicated regulation by cadmium-induced oxidative-stress related signaling pathways. This study provides valuable information on 99 conserved Atg genes involved in autophagosome formation in Brachionus spp., with transcriptional modulation in response to cadmium, in the context of the role of autophagy in the damage response.

KeywordAutophagy Autophagy-related genes Atg Rotifer Brachionus spp.
DOI10.1016/j.aquatox.2018.05.021
Funding OrganizationNational Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique
Indexed BySCI
Language英语
Funding ProjectNational Research Foundation[2017R1D1A1B03032814] ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique[PE99624]
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000440530000009
WOS KeywordCELL-DEATH ; SACCHAROMYCES-CEREVISIAE ; MEDIATED AUTOPHAGY ; OXIDATIVE STRESS ; MODEL SELECTION ; COMPLEX ; PROTEIN ; EXPRESSION ; KOREANUS ; PATHWAY
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; National Research Foundation ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique ; grant of Development of risk assessment for control technology to reduce transfer of ship's biofouling: In-water cleaning technique
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30553
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLee, Jae-Seong; Jeong, Chang-Bum
Affiliation1.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea
2.Korea Inst Ocean Sci & Technol, Oil & POPs Res Grp, Geoje 53201, South Korea
3.Nagasaki Univ, Grad Sch Fisheries & Environm Sci, Nagasaki 8528521, Japan
4.Nagasaki Univ, Org Marine Sci & Technol, Nagasaki 8528521, Japan
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714		 Kang, Hye-Min,Lee, Jin-Sol,Kim, Min-Sub,et al. Genome-wide identification of 99 autophagy-related (Atg) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium[J]. AQUATIC TOXICOLOGY,2018,201(1):73-82.
APA Kang, Hye-Min.,Lee, Jin-Sol.,Kim, Min-Sub.,Lee, Young Hwan.,Jung, Jee-Hyun.,...&Jeong, Chang-Bum.(2018).Genome-wide identification of 99 autophagy-related (Atg) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium.AQUATIC TOXICOLOGY,201(1),73-82.
MLA Kang, Hye-Min,et al."Genome-wide identification of 99 autophagy-related (Atg) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium".AQUATIC TOXICOLOGY 201.1(2018):73-82.
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