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The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury
Zhang, Xiaofan1,2,3; El Demerdash, Nagat1; Falck, John R.4; Munnuri, Sailu4; Koehler, Raymond C.1; Yang, Zeng-Jin1
Corresponding AuthorYang, Zeng-Jin(zyang4@jhmi.edu)
2018-07-01
Source PublicationPROSTAGLANDINS & OTHER LIPID MEDIATORS
ISSN1098-8823
Volume137Pages:63-68
Abstract20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 (CYP) 4A/4F-derived metabolite of arachidonic acid, directly contributes to ischemic neuronal injury. However, little is known about mediators of 20-HETE neurotoxicity after ischemia. Here, we focus on the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in 20-HETE-induced neurotoxicity. Our results showed that TRPV1 and CYP4A irnmunoreactivity were colocalized in neurons. TRPV1 inhibition attenuated 20-HETE mimetic 20-5,14-HEDGE-induced reactive oxygen species (ROS) production and neuronal injury in cultured neurons and protected ischemic neurons in vitro and in vivo. TRPV1 inhibition in combination with 20-HETE synthesis inhibitor HET0016 did not produce additional protective effects. Furthermore, TRPV1 genetic inhibition and NADPH oxidase inhibitor gp9lds-dat each attenuated ROS production to a similar extent. However, combined treatment did not achieve additional reduction. Therefore, we conclude that TRPV1 channels are involved in 20-HETE's ROS generation and neurotoxicity after ischemia.
Keyword20-HETE TRPV1 Oxygen-glucose deprivation Hypoxic-ischemic injury Neonatal
DOI10.1016/j.prostaglandins.2018.07.001
Funding OrganizationChinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
Indexed BySCI ; SCI
Language英语
Funding ProjectChinese Scholarship Council ; National Institutes of Health (NIH)[HL139793] ; Robert A. Welch Foundation[I-0011] ; NIH[NS060703] ; NIH[NS067525] ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000440957900008
WOS KeywordOXYGEN-GLUCOSE DEPRIVATION ; CEREBRAL-ARTERY OCCLUSION ; 20-HYDROXYEICOSATETRAENOIC ACID ; INDUCED HYPOTHERMIA ; 20-HETE INHIBITION ; CORTICAL-NEURONS ; SMOOTH-MUSCLE ; CELL-DEATH ; RECEPTOR ; MICE
PublisherELSEVIER SCIENCE INC
Funding OrganizationChinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; Chinese Scholarship Council ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; Robert A. Welch Foundation ; NIH ; NIH ; NIH ; NIH ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University ; Stimulating and Advancing ACCM Research (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30550
Collection其他_期刊论文
Corresponding AuthorYang, Zeng-Jin
Affiliation1.Johns Hopkins Univ, Dept Anesthesiol Crit Care Med, 720 Rutland Ave,Traylor 804, Baltimore, MD 21205 USA
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
Recommended Citation
GB/T 7714
Zhang, Xiaofan,El Demerdash, Nagat,Falck, John R.,et al. The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury[J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS,2018,137:63-68.
APA Zhang, Xiaofan,El Demerdash, Nagat,Falck, John R.,Munnuri, Sailu,Koehler, Raymond C.,&Yang, Zeng-Jin.(2018).The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury.PROSTAGLANDINS & OTHER LIPID MEDIATORS,137,63-68.
MLA Zhang, Xiaofan,et al."The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury".PROSTAGLANDINS & OTHER LIPID MEDIATORS 137(2018):63-68.
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