Health risks associated with genetic alterations in internal clock system by external factors | |
Khan, Suliman1,2,3; Nabi, Ghulam1,3; Yao, Lunguang2; Siddique, Rabeea4,5; Sajjad, Wasim3,6; Kumar, Sunjeet1; Duan, Pengfei2; Hou, Hongwei1![]() | |
2018 | |
Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
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ISSN | 1449-2288 |
Volume | 14Issue:7Pages:791-798 |
Abstract | The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep. |
Keyword | Circadian system sleep health risks clock genes |
DOI | 10.7150/ijbs.23744 |
Funding Organization | Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; 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CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship |
Indexed By | SCI |
Language | 英语 |
Funding Project | Scientific research and service platform fund of Henan Province[2016151] ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province[17454] ; CAS-TWAS president's fellowship |
WOS Research Area | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
WOS Subject | Biochemistry & Molecular Biology ; Biology |
WOS ID | WOS:000433261800010 |
WOS Keyword | GLUCOSE-METABOLISM IMPLICATIONS ; SLEEP-PHASE SYNDROME ; CIRCADIAN CLOCK ; SHIFT-WORK ; THERAPEUTIC IMPLICATIONS ; MOLECULAR-COMPONENTS ; LIGHT EXPOSURE ; FOOD-INTAKE ; JET-LAG ; DISORDER |
Publisher | IVYSPRING INT PUBL |
Funding Organization | Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; 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fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; 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fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; Scientific research and service platform fund of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship ; CAS-TWAS president's fellowship |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/30497 |
Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
Corresponding Author | Yao, Lunguang; Hou, Hongwei |
Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China 2.Nanyang Normal Univ, Henan Key Lab Ecol Secur Water Source Reg Mid Lin, Collaborat Innovat Ctr Water Secur Water Source R, Nanyang, Henan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Huazhong Univ Sci & Technol, Adv Biomat & Tissue Engn Ctr, Wuhan 430074, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan 430074, Hubei, Peoples R China 6.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Petr Resources, Gansu Prov Key Lab Petr Resources Res, Lanzhou 730000, Gansu, Peoples R China |
Recommended Citation GB/T 7714 | Khan, Suliman,Nabi, Ghulam,Yao, Lunguang,et al. Health risks associated with genetic alterations in internal clock system by external factors[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2018,14(7):791-798. |
APA | Khan, Suliman.,Nabi, Ghulam.,Yao, Lunguang.,Siddique, Rabeea.,Sajjad, Wasim.,...&Hou, Hongwei.(2018).Health risks associated with genetic alterations in internal clock system by external factors.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14(7),791-798. |
MLA | Khan, Suliman,et al."Health risks associated with genetic alterations in internal clock system by external factors".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14.7(2018):791-798. |
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