IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Transcriptomic Profiles of Brain Provide Insights into Molecular Mechanism of Feed Conversion Efficiency in Crucian Carp (Carassius auratus)
Pang, Meixia1,2; Luo, Weiwei1; Fu, Beide1; Yu, Xiaomu1; Zhou, Ying1,2; Tong, Jingou1
Corresponding AuthorTong, Jingou(jgtong@ihb.ac.cn)
2018-03-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume19Issue:3Pages:14
AbstractFeed efficiency is an economically crucial trait for cultured animals, however, progress has been scarcely made in the genetic analyses of feed conversion efficiency (FCE) in fish because of the difficulties in measurement of trait phenotypes. In the present investigation, we present the first application of RNA sequencing (RNA-Seq) combined with differentially expressed genes (DEGs) analysis for identification of functional determinants related to FCE at the gene level in an aquaculture fish, crucian carp (Carassius auratus). Brain tissues of six crucian carp with extreme FCE performances were subjected to transcriptome analysis. A total of 544,612 unigenes with a mean size of 644.38 bp were obtained from Low- and High-FCE groups, and 246 DEGs that may be involved in FCE traits were identified in these two groups. qPCR confirmed that genes previously identified as up- or down-regulated by RNA-Seq were effectively up- or down-regulated under the studied conditions. Thirteen key genes, whose functions are associated with metabolism (Dgkk, Mgst3 and Guk1b), signal transduction (Vdnccsalb, Tgf alpha, Nr4a1 and Tacr2) and growth (Endog, Crebrtc2, Myh7, Myh1, Myh14 and Igfbp7) were identified according to GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) annotations. Our novel findings provide useful pathway information and candidate genes for future studies of genetic mechanisms underlying FCE in crucian carp.
Keywordcrucian carp (Carassius auratus) feed conversion efficiency brain differentially expressed genes RNA-Seq
DOI10.3390/ijms19030858
Funding OrganizationSpecial Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectSpecial Fund for Strategic Pilot Technology of Chinese Academy of Sciences[XDA08010405] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ05]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000428309800215
WOS KeywordQUANTITATIVE TRAIT LOCI ; CANDIDATE GENES ; CLIMATE-CHANGE ; BEEF-CATTLE ; GENOME ; IDENTIFICATION ; GROWTH ; FOOD ; PERSPECTIVES ; ASSOCIATION
PublisherMDPI
Funding OrganizationSpecial Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30435
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorTong, Jingou
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Pang, Meixia,Luo, Weiwei,Fu, Beide,et al. Transcriptomic Profiles of Brain Provide Insights into Molecular Mechanism of Feed Conversion Efficiency in Crucian Carp (Carassius auratus)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(3):14.
APA Pang, Meixia,Luo, Weiwei,Fu, Beide,Yu, Xiaomu,Zhou, Ying,&Tong, Jingou.(2018).Transcriptomic Profiles of Brain Provide Insights into Molecular Mechanism of Feed Conversion Efficiency in Crucian Carp (Carassius auratus).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(3),14.
MLA Pang, Meixia,et al."Transcriptomic Profiles of Brain Provide Insights into Molecular Mechanism of Feed Conversion Efficiency in Crucian Carp (Carassius auratus)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.3(2018):14.
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