IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/beta-Catenin activity
Liu, Jing-Xia1,2; Xu, Qin-Han1; Yu, XueDong1; Zhang, Ting1; Xie, XunWei2; Ouyang, Gang2
2018
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume14Issue:7Pages:705-716
Abstract

During early vertebrate embryogenesis, maternal Wnt/beta-catenin signaling is thought to locally initiate expression of dorsal-specific genes. Here, eaf1 and eaf2 were identified as important maternal and zygotic modulators of Wnt signaling to initiate and specify ventral genes. Expression of ventral ved, vent, and vox was all obviously enhanced in either maternal or zygotic eaf1/2 morphants, and in both eaf1 heterozygous and homozygous mutants, but their expression was suppressed in embryos with over-expression of eaf1/2. Additionally, eaf1/2 were revealed to suppress ventral fates in embryos via Wnt/beta-catenin 1/Tcf signaling, complimentary to their roles in suppressing dorsal fates via Wnt/beta-catenin2 signaling. Moreover, eaf1/2 were also revealed to obviously suppress the expression of axin2 induced by beta-catenin2 rather than by beta-catenin1, and the dorsal expression of axin2 in embryos was obviously suppressed by ectopic expression of eaf1/2. This study uncovers a novel dorsal-ventral patterning pathway, with eaf1 and eaf2 inhibiting ventral cells via suppressing Wnt/beta-catenin 1/Tcf signaling and inducing dorsal cells indirectly via suppressing beta-catenin2-induced-axin2 on the dorsal side of embryos.

Keywordeaf1 eaf2 beta-catenin axin2 dorsal-ventral patterning
DOI10.7150/ijbs.18997
Funding OrganizationChinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; 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Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation
Indexed BySCI
Language英语
Funding ProjectChinese Academy of Science[KSCX2-EW-Q-12] ; Fundamental Research Funds for the Central Universities[2662015PY002] ; Agricultural University Scientific & Technological Self-Innovation Foundation[42000481-7-2014RC007]
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000433261800002
WOS KeywordBETA-CATENIN ; SIGNALING PATHWAY ; DORSOVENTRAL AXIS ; XENOPUS EMBRYOS ; MESODERM ; ROLES ; ORGANIZER ; HOMOLOG ; PROTEIN ; GENES
PublisherIVYSPRING INT PUBL
Funding OrganizationChinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Agricultural University Scientific & Technological Self-Innovation Foundation ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Chinese Academy of Science ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; 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Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30373
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorLiu, Jing-Xia
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Anim Breeding, Minist Agr, Wuhan 430070, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jing-Xia,Xu, Qin-Han,Yu, XueDong,et al. Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/beta-Catenin activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2018,14(7):705-716.
APA Liu, Jing-Xia,Xu, Qin-Han,Yu, XueDong,Zhang, Ting,Xie, XunWei,&Ouyang, Gang.(2018).Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/beta-Catenin activity.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14(7),705-716.
MLA Liu, Jing-Xia,et al."Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/beta-Catenin activity".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14.7(2018):705-716.
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