IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila
Zhang, Jing1,2; Yan, Guanxiong1,2; Tian, Miao1; Ma, Yang1,2; Xiong, Jie1; Miao, Wei1
2018
Source PublicationCELL CYCLE
ISSN1538-4101
Volume17Issue:5Pages:634-642
Abstract

Evolutionarily conserved E2F family transcription factors regulate the cell cycle via controlling gene expression in a wide range of eukaryotes. We previously demonstrated that the meiosis-specific transcription factor E2fl1 had an important role in meiosis in the model ciliate Tetrahymena thermophila. Here, we report that expression of another E2F family transcription factor gene DPL2 correlates highly with that of E2FL1. Similar to e2fl1 Delta cells, dpl2 Delta cells undergo meiotic arrest prior to anaphase I, with the five chromosomes adopting an abnormal tandem arrangement. Immunofluorescence staining and immunoprecipitation experiments demonstrate that Dpl2 and E2fl1 form a complex during meiosis. We previously identified several meiotic regulatory proteins in T. thermophila. Cyc2 and Tcdk3 may cooperate to initiate meiosis and Cyc17 is essential for initiating meiotic anaphase. We investigate the relationship of these regulators with Dpl2 and E2fl1, and then construct a meiotic regulatory network by measuring changes in meiotic genes expression in knockout cells. We conclude that the E2fl1/Dpl2 complex plays a central role in meiosis in T. thermophila.

KeywordTetrahymena thermophila meiosis transcription factor E2fl1/Dpl2 complex network
DOI10.1080/15384101.2018.1431595
Funding OrganizationNatural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; 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Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[31525021] ; Natural Science Foundation of China[91631303] ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China[2013DFG32390]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000430934900013
WOS KeywordSYNAPTONEMAL COMPLEX ; PROTIST TETRAHYMENA ; MEIOTIC RECOMBINATION ; STRUCTURAL BASIS ; TARGET GENES ; RNA-SEQ ; CYCLE ; DNA ; PATHWAY ; EXPRESSION
PublisherTAYLOR & FRANCIS INC
Funding OrganizationNatural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; 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Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30341
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorMiao, Wei
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jing,Yan, Guanxiong,Tian, Miao,et al. A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila[J]. CELL CYCLE,2018,17(5):634-642.
APA Zhang, Jing,Yan, Guanxiong,Tian, Miao,Ma, Yang,Xiong, Jie,&Miao, Wei.(2018).A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila.CELL CYCLE,17(5),634-642.
MLA Zhang, Jing,et al."A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila".CELL CYCLE 17.5(2018):634-642.
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