IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot, Scophthalmus maximus L.
Chen, Zhichu1; Liu, Yang1; Li, Yanxian1; Yang, Pei1; Hu, Haibin1; Yu, Guijuan1; Ai, Qinghui1; Xu, Wei1; Zhang, Wenbing1; Zhang, Yongan2; Zhang, Yanjiao1; Mai, Kangsen1
2018-04-01
Source PublicationAQUACULTURE RESEARCH
ISSN1355-557X
Volume49Issue:4Pages:1535-1545
Abstract

A 12-week feeding trial was conducted to investigate the protective effects of arginine on the intestinal health of juvenile turbot (Scophthalmus maximus L.) fed high doses of dietary soybean meal. Sextuple replicates of 30 fish were fed each of four isonitrogenous and isolipidic experimental diets: fish-meal-based diet (FM); FM with 40% fish meal protein replaced by soybean meal protein (SBM); SBM+1% arginine (ARG1) and SBM+2% arginine (ARG2). Turbot-fed SBM showed typical soybean meal-induced enteropathy, characterized by an increase in the thickness of lamina propria, as well as significant decreases in the absorptive surface and activities of intestinal brush border membrane enzymes and Na+, K+-ATPase. On the contrary, fish-fed ARG1 showed enhanced intestinal mucosal barrier function in terms of the enhanced gene expression of anti-inflammatory cytokine and barrier-forming tight junction proteins, as well as depressed gene expression of pro-inflammatory cytokines and pore-forming tight junction proteins. Fish-fed AGR2 showed intermediate intestinal performances between SBM and AGR1. Dietary arginine (1%) also significantly regulated the expression of AMP-activated protein kinase alpha 1 (AMPK alpha 1), myosin light chain kinase (MLCK) and nuclear transcription factor-kappa B p65 (NF-kappa B p65), and these regulations correlated well with its regulations on intestinal mucosal barrier related genes at all sampling time-points. In conclusion, arginine supplementation (1%) in diet for turbot mitigated the soybean meal-induced enteropathy by enhancing the intestinal mucosal barrier function. The activation of AMPK alpha 1 signalling molecule as well as the suppression of NF-kappa B p65 and MLCK signalling molecules may mediate the beneficial effects of arginine.

Keywordarginine enteropathy intestinal mucosal barrier soybean meal turbot
DOI10.1111/are.13608
Funding OrganizationNational Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System
Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program[2014CB138601] ; National Natural Science Foundation of China[41576137] ; National Natural Science Foundation of China[31202006] ; China Agriculture Researches System[CARS 50-G08]
WOS Research AreaFisheries
WOS SubjectFisheries
WOS IDWOS:000427003200017
WOS KeywordMESSENGER-RNA EXPRESSION ; SALMON SALMO-SALAR ; CARPIO VAR. JIAN ; NF-KAPPA-B ; GROWTH-PERFORMANCE ; IMMUNE-RESPONSES ; EXPERIMENTAL COLITIS ; DISTAL INTESTINE ; BARRIER FUNCTION ; GENE-EXPRESSION
PublisherWILEY
Funding OrganizationNational Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/30338
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorZhang, Yanjiao
Affiliation1.Ocean Univ China, Key Lab Mariculture, Minist Educ, Key Lab Aquaculture Nutr & Feed,Minist Agr, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhichu,Liu, Yang,Li, Yanxian,et al. Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot, Scophthalmus maximus L.[J]. AQUACULTURE RESEARCH,2018,49(4):1535-1545.
APA Chen, Zhichu.,Liu, Yang.,Li, Yanxian.,Yang, Pei.,Hu, Haibin.,...&Mai, Kangsen.(2018).Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot, Scophthalmus maximus L..AQUACULTURE RESEARCH,49(4),1535-1545.
MLA Chen, Zhichu,et al."Dietary arginine supplementation mitigates the soybean meal induced enteropathy in juvenile turbot, Scophthalmus maximus L.".AQUACULTURE RESEARCH 49.4(2018):1535-1545.
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