IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
The dose makes the poison
Chen, Liang1,2; Giesy, John P.3,4; Xie, Ping1,5
Corresponding AuthorXie, Ping(xieping@ihb.ac.cn)
2018-04-15
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume621Pages:649-653
AbstractSome microcystins (MCs) might cause hepatotoxicity in animals and humans. MC-LR is also a tumor promoter and a suspect carcinogen. In 2010, the International Agency for Research on Cancer (IARC) classified MC-LR as a possible human carcinogen (Group 2B). Recently, an article entitled "Long-term, low-dose exposure to microcystin toxin does not increase the risk of liver tumor development or growth in mice"was published in Hepatology Research by Meaghan Labine and Gerald Y. Minuk. However, the experimental design was flawed and the conclusion is misleading. 1 mu g/L MC-LR in drinking water is the provisional guideline value established by the World Health Organization (WHO) for humans in 1998, based on a tolerable daily intake (TDI) of 0.04 mu g/kg body mass (BM). Assuming the mice drink 1.5 mL/10 g BM of water per day, the exposure dose would be 0.15 mu g/kg/d BM, about 270-fold less than 40 mu g/kg/d, the no-observed-adverse-effect level (NOAEL). Thus, the dose of MC-LR was too small and "unlikely to result in liver tumor development or enhance existing tumor growth", even with a long-term (28 weeks) exposure. Presumably, they didn't consider inter-species variations between mice and humans, including toxicokinetics and toxicodynamics. Ranges of "low-dose"MCs for animals and humans should be defined. Also, the authorsmisunderstood or misrepresented several previous studies. Before drawing final conclusions on the carcinogenicity of MCs, further well-designed experiments are warranted. (C) 2017 Elsevier B.V. All rights reserved.
KeywordMicrocystin Low-dose Tumor Equivalent doses Inter-species variations Experimental design
DOI10.1016/j.scitotenv.2017.11.218
Funding OrganizationNational Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundations of China[31770555] ; National Natural Science Foundations of China[31600423] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ08] ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China[GDT20143200016] ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000424196800065
WOS KeywordMICROCYSTIN-LR ; CYANOBACTERIAL TOXINS ; POTENTIAL CARCINOGENICITY ; COMPARATIVE TOXICOLOGY ; TOXICITY ; GLUTATHIONE ; MOUSE ; RISK ; RAT ; IDENTIFICATION
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; National Natural Science Foundations of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs, the P.R. China ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29957
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, Ping
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
4.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
5.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810016, Peoples R China
Recommended Citation
GB/T 7714
Chen, Liang,Giesy, John P.,Xie, Ping. The dose makes the poison[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,621:649-653.
APA Chen, Liang,Giesy, John P.,&Xie, Ping.(2018).The dose makes the poison.SCIENCE OF THE TOTAL ENVIRONMENT,621,649-653.
MLA Chen, Liang,et al."The dose makes the poison".SCIENCE OF THE TOTAL ENVIRONMENT 621(2018):649-653.
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