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Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae
Zhu, Biran1,2; Zhao, Gang2; Yang, Lihua1; Zhou, Bingsheng1
2018-04-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume197Issue:1Pages:353-361
Abstract

Tetrabromobisphenol A (TBBPA), one of the most widely used brominated flame retardants (BFRs), has resulted in worldwide environmental contamination. TBBPA has been reported as a thyroid endocrine disruptor and a potential neurotoxicant. However, the underlying mechanism is still not clear. In this study, zebrafish (Danio rerio) embryos (2 h post-fertilization, hpf) were exposed to different concentrations of TBBPA (50, 100, 200 and 400 mu g/L) alone or in combination with 3,3',5-triiodo-l-thyronine (T3, 20 TBBPA, 200 mu g/L). The results confirmed that TBBPA could evoke thyroid disruption by observations of increased T4 contents and decreased T3 contents, accompanied by up-regulated tsh beta, tg mRNA and down-regulated ttr and tr beta mRNA levels in zebafish larvae. TBBPA-induced neuro-developmental toxicity was also indicated by down-regulated transcription of genes related to central nervous system (CNS) development (e.g., alpha l-tubulin, mbp and shha), and decreased locomotor activity and average swimming speed. Our results further demonstrated that treatment with T3 could reverse or eliminate TBBPA-induced effects on thyroidal and neurodevelopmental parameters. Given the above, we hypothesize that the observed neurodevelopmental toxicity in the present study could be attributed to the thyroid hormone disruptions by TBBPA. (C) 2018 Elsevier Ltd. All rights reserved.

KeywordTetrabromobisphenol A (TBBPA) Zebrafish (Danio rerio) Thyroid disruption Neurodevelopmental toxicity
DOI10.1016/j.chemosphere.2018.01.080
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; 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Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; 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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21737005] ; National Natural Science Foundation of China[21307153] ; Young Plan from Hubei University of Traditional Chinese Medicine[2016ZZX003] ; Educational Commission of Hubei Province of China[Q20161011]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000426231900040
WOS KeywordDECABROMODIPHENYL ETHER BDE-209 ; BROMINATED FLAME RETARDANTS ; DANIO-RERIO ; A TBBPA ; EXPOSURE ; EXPRESSION ; RECEPTOR ; LEAD ; AXIS ; BIOCONCENTRATION
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Young Plan from Hubei University of Traditional Chinese Medicine ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China ; Educational Commission of Hubei Province of China
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29729
Collection水环境工程研究中心_期刊论文
Corresponding AuthorYang, Lihua
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Hubei Univ Chinese Med, Dept Basic Med, Wuhan 430065, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Biran,Zhao, Gang,Yang, Lihua,et al. Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae[J]. CHEMOSPHERE,2018,197(1):353-361.
APA Zhu, Biran,Zhao, Gang,Yang, Lihua,&Zhou, Bingsheng.(2018).Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae.CHEMOSPHERE,197(1),353-361.
MLA Zhu, Biran,et al."Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae".CHEMOSPHERE 197.1(2018):353-361.
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