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Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate
Chen, Lianguo1,3; Hu, Chenyan4; Tsui, Mirabelle M. P.1; Wan, Teng2; Peterson, Drew R.2; Shi, Qipeng3; Lam, Paul K. S.1; Au, Doris W. T.2; Lam, James C. W.1,5; Zhou, Bingsheng3
Corresponding AuthorLam, James C. W.(jameslam@eduhk.hk) ; Zhou, Bingsheng(bszhou@ihb.ac.cn)
2018-04-03
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume52Issue:7Pages:4432-4439
AbstractAccumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about its ecological safety. However, hazardous effects of PFBS remain largely unexplored, especially for endocrine disrupting potency. In the present study, the multigenerational endocrine disrupting potential of PFBS was investigated by exposing F0 marine medaka eggs to PFBS at different concentrations (0, 1.0, 2.9, and 9.5 mu g/L) until sexual maturity. The F1 and F2 generations were reared without continued exposure. Thyroidal disturbances were examined in all three generations. PFBS exposure decreased the levels of 3,5,3'-triiodothyronine (T3) in F0 female blood; however, it increased T3 or thyroxine (T4) levels in F0 brains, in which hyperthyroidism suppressed the local transcription of 5'-deiodinase 2 (Dio2). Obviously decreased T3 was transferred to F1 eggs, although the parental influences were reversed in F1 larvae. Delayed hatching was coupled with elevated T3 levels in F1 larvae. F1 adults showed comparable symptoms of thyroidal disruption with F0 adults. A slight recovery was noted in the F2 generation, although F2 larvae still exhibited thyroid disruption and synthesized excessive T4. Our results suggested that the offspring suffered more severe dysfunction of the thyroidal axis albeit without direct exposure. This study provided the first molecular insight about PFBS toxicology on the thyroid, beneficial to both human and environmental risk assessment.
DOI10.1021/acs.est.8b00700
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong
Indexed BySCI ; SCI
Language英语
Funding ProjectResearch Grants Council Theme-Based Research Scheme[T21-602/16-R] ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20160608153654409] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; National Natural Science Foundation of China[21737005] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ11] ; Education University of Hong of Kong
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000429385700066
WOS KeywordSPRAGUE-DAWLEY RATS ; SOUTH CHINA SEA ; 4,5-DICHLORO-2-N-OCTYL-4-ISOTHIAZOLIN-3-ONE DCOIT ; POTASSIUM PERFLUOROBUTANESULFONATE ; ORYZIAS-MELASTIGMA ; SUBSTANCES PFASS ; ORAL GAVAGE ; PERFLUOROALKYL ; ZEBRAFISH ; IDENTIFICATION
PublisherAMER CHEMICAL SOC
Funding OrganizationResearch Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong ; Education University of Hong of Kong
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29552
Collection水环境工程研究中心_期刊论文
Corresponding AuthorLam, James C. W.; Zhou, Bingsheng
Affiliation1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China
5.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo,Hu, Chenyan,Tsui, Mirabelle M. P.,et al. Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(7):4432-4439.
APA Chen, Lianguo.,Hu, Chenyan.,Tsui, Mirabelle M. P..,Wan, Teng.,Peterson, Drew R..,...&Zhou, Bingsheng.(2018).Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(7),4432-4439.
MLA Chen, Lianguo,et al."Multigenerational Disruption of the Thyroid Endocrine System in Marine Medaka after a Life-Cycle Exposure to Perfluorobutanesulfonate".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.7(2018):4432-4439.
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