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Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae
Zhang, Shengnan1,2; Guo, Xiaochun2; Lu, Shaoyong2; Sang, Nan1; Li, Guangyu3; Xie, Ping4; Liu, Chunsheng3; Zhang, Liguo1; Xing, Yi5
2018-04-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume235Issue:1Pages:974-982
Abstract

Perfiuorododecanoic acid (PFDoA), a kind of perfluorinated carboxylic acid (PFCA) with 12 carbon atoms, has an extensive industrial utilization and is widespread in both wildlife and the water environment, and was reported to have the potential to cause a disruption in the thyroid hormone system homeostasis. In this study, zebrafish embryos larvae were exposed to different concentrations of PFDoA (0, 0.24, 1.2, 6 mg/L) for 96 h post-fertilization (hpf). PFDoA exposure caused obvious growth restriction connected with the reduced thyroid hormones (THs) contents in zebrafish larvae, strengthening the interference effect on the growth of fish larvae. The transcriptional level of genes within the hypothalamic-pituitary thyroid (HPT) axis was analyzed. The gene expression levels of thyrotropin-releasing hormone (trh) and corticotrophin-releasing hormone (crh) were upregulated upon exposure to 6 mg/L of PFDoA, and iodothyronine deiodinases (dio2) was upregulated in the 1.2 mg/L PFDoA group. The transcription of thyroglobulin (tg) and thyroid receptor (tr beta) were significantly downregulated upon exposure to 1.2 mg/L and 6 mg/L of PFDoA. PFDoA could also decrease the levels of sodium/iodide symporter (nis) and transthyretin (ttr) gene expression in a concentration-dependent manner after exposure. A significant decrease in thyroid-stimulating hormone5 (tsh beta), uridinediphosphate-glucuronosyltransferase (ugt1ab) and thyroid receptor (tr alpha) gene expression were observed at 6 mg/L PFDoA exposure. Upregulation and downregulation of iodothyronine deiodinases (diol) gene expression were observed upon the treatment of 1.2 mg/L and 6 mg/L PFDoA, respectively. All the data demonstrated that gene expression in the HPT axis altered after different PFDoA treatment and the potential mechanisms of the disruption of thyroid status could occur at several steps in the process of synthesis, regulation, and action of thyroid hormones. (C) 2018 Elsevier Ltd. All rights reserved.

KeywordPFDoA Zebrafish embryos Hypothalamus-pituitary-thyroid axis Thyroid disruption
DOI10.1016/j.envpol.2018.01.015
Funding OrganizationNational Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China
Indexed BySCI
Language英语
Funding ProjectNational Nature Science Foundation of China (NSFC)[41601544] ; Ministry of Science and Technology of China[2015FY11-0900]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000428100200102
WOS KeywordPERFLUOROOCTANE SULFONATE PFOS ; CARBON-CHAIN LENGTH ; DECABROMODIPHENYL ETHER BDE-209 ; PERFLUORINATED FATTY-ACIDS ; MINNOW GOBIOCYPRIS-RARUS ; SHORT-TERM EXPOSURE ; LIFE-CYCLE TEST ; ENDOCRINE DISRUPTION ; GENE-EXPRESSION ; HORMONE LEVELS
PublisherELSEVIER SCI LTD
Funding OrganizationNational Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; National Nature Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29543
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorLu, Shaoyong; Sang, Nan
Affiliation1.Shanxi Univ, Coll Environm & Resource, Taiyuan 030006, Shanxi, Peoples R China
2.Chinese Res Inst Environm Sci, Natl Engn Lab Lake Pollut Control & Ecol Restorat, State Key Lab Environm Criteria & Risk Assessment, Res Ctr Lake Environm,SEPSORSLD, Beijing 100012, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Hubei, Peoples R China
5.Univ Sci & Technol Beijing, Sch Energy & Environm Engn, Beijing 100012, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Shengnan,Guo, Xiaochun,Lu, Shaoyong,et al. Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae[J]. ENVIRONMENTAL POLLUTION,2018,235(1):974-982.
APA Zhang, Shengnan.,Guo, Xiaochun.,Lu, Shaoyong.,Sang, Nan.,Li, Guangyu.,...&Xing, Yi.(2018).Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae.ENVIRONMENTAL POLLUTION,235(1),974-982.
MLA Zhang, Shengnan,et al."Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae".ENVIRONMENTAL POLLUTION 235.1(2018):974-982.
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