IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.
Liu, Yang1,2; Chen, Zhichu1,2; Dai, Jihong1,2; Yang, Pei1,2; Hu, Haibin1,2; Ai, Qinghui1,2; Zhang, Wenbing1,2; Zhang, Yongan4; Zhang, Yanjiao1,2,3; Mai, Kangsen1,2,3
2018-12-01
Source PublicationAQUACULTURE
ISSN0044-8486
Volume497Issue:1Pages:510-519
Abstract

The aim of this study is to investigate the protective effect and regulatory mechanism of Gln on the enteropathy of turbot induced by soybean meal. Three isonitrogenous and isolipidic practical diets were formulated with fish meal basis (FM), soy protein replacing 40% fish meal protein (SBM) and dietary 2% Ala-Gln in SBM (Ala-Gin) for sextuple replicates of 30 fish each tank for 12 weeks. The fish in SBM group presented distinct enteropathy including declined absorptive surface and overt infiltration of mixed leukocytes in the lamina propria. However, the turbot fed Ala-Gln diet showed the integrity of the intestinal tissue structure and higher ADC and AKP levels like fish in FM group. Compared to SBM group, the inclusion of 2% Ala-Gln in SBM-basal diet significantly elevated the expression of barrier-forming tight junction proteins claudin-4, occludin and ZO-1 and depressed the expression of pro-inflammatory cytokines TNF-alpha in the intestine. Fish fed Ala-Gln diet showed remarkable increased MUC-2 and PPAR-gamma gene expression as well as reduced expression of NF-kappa B and MLCK equivalent to the level of FM group. Additionally, Gln significantly elevated the relative abundance of Proteobacteria (Vibrio spp.) and declined Bacteroidetes (Bacteroides spp.) relative abundance. The similarity of intestinal microbial communities in Ala-Gln group was notably closer to FM group from PCoA, UPGMA and Heatmap analyses based on weighted UniFrac distance. In conclusion, dietary Gln could probably enhance intestinal barrier function to alleviate enteropathy by improving MUC-2 and PPAR-gamma expression and inhibiting NF-kappa B-MLCK signaling pathway, as well as altering microbiota.

KeywordGlutamine Soybean meal Enteropathy Intestinal mucosal barrier Intestinal microbiota Turbot
DOI10.1016/j.aquaculture.2018.08.021
Funding OrganizationNational Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System
Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program (973 program)[2014CB138601] ; National Natural Science Foundation of China[41576137] ; National Natural Science Foundation of China[31202006] ; China Agriculture Researches System[CARS 47-G10]
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS IDWOS:000442900300062
WOS KeywordNF-KAPPA-B ; TURBOT SCOPHTHALMUS-MAXIMUS ; SALMO-SALAR L. ; ACTIVATED-RECEPTOR-GAMMA ; LIGHT-CHAIN KINASE ; BARRIER FUNCTION ; ATLANTIC SALMON ; INTESTINAL MICROBIOTA ; PPAR-GAMMA ; EPITHELIAL BARRIER
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29471
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorZhang, Yanjiao
Affiliation1.Ocean Univ China, Minist Agr, Key Lab Aquaculture Nutr & Feed, Qingdao 266003, Peoples R China
2.Ocean Univ China, Minist Educ, Key Lab Mariculture, Qingdao 266003, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yang,Chen, Zhichu,Dai, Jihong,et al. The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.[J]. AQUACULTURE,2018,497(1):510-519.
APA Liu, Yang.,Chen, Zhichu.,Dai, Jihong.,Yang, Pei.,Hu, Haibin.,...&Mai, Kangsen.(2018).The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L..AQUACULTURE,497(1),510-519.
MLA Liu, Yang,et al."The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.".AQUACULTURE 497.1(2018):510-519.
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