The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L. | |
Liu, Yang1,2; Chen, Zhichu1,2; Dai, Jihong1,2; Yang, Pei1,2; Hu, Haibin1,2; Ai, Qinghui1,2; Zhang, Wenbing1,2; Zhang, Yongan4; Zhang, Yanjiao1,2,3; Mai, Kangsen1,2,3 | |
2018-12-01 | |
Source Publication | AQUACULTURE
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ISSN | 0044-8486 |
Volume | 497Issue:1Pages:510-519 |
Abstract | The aim of this study is to investigate the protective effect and regulatory mechanism of Gln on the enteropathy of turbot induced by soybean meal. Three isonitrogenous and isolipidic practical diets were formulated with fish meal basis (FM), soy protein replacing 40% fish meal protein (SBM) and dietary 2% Ala-Gln in SBM (Ala-Gin) for sextuple replicates of 30 fish each tank for 12 weeks. The fish in SBM group presented distinct enteropathy including declined absorptive surface and overt infiltration of mixed leukocytes in the lamina propria. However, the turbot fed Ala-Gln diet showed the integrity of the intestinal tissue structure and higher ADC and AKP levels like fish in FM group. Compared to SBM group, the inclusion of 2% Ala-Gln in SBM-basal diet significantly elevated the expression of barrier-forming tight junction proteins claudin-4, occludin and ZO-1 and depressed the expression of pro-inflammatory cytokines TNF-alpha in the intestine. Fish fed Ala-Gln diet showed remarkable increased MUC-2 and PPAR-gamma gene expression as well as reduced expression of NF-kappa B and MLCK equivalent to the level of FM group. Additionally, Gln significantly elevated the relative abundance of Proteobacteria (Vibrio spp.) and declined Bacteroidetes (Bacteroides spp.) relative abundance. The similarity of intestinal microbial communities in Ala-Gln group was notably closer to FM group from PCoA, UPGMA and Heatmap analyses based on weighted UniFrac distance. In conclusion, dietary Gln could probably enhance intestinal barrier function to alleviate enteropathy by improving MUC-2 and PPAR-gamma expression and inhibiting NF-kappa B-MLCK signaling pathway, as well as altering microbiota. |
Keyword | Glutamine Soybean meal Enteropathy Intestinal mucosal barrier Intestinal microbiota Turbot |
DOI | 10.1016/j.aquaculture.2018.08.021 |
Funding Organization | National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System |
Indexed By | SCI |
Language | 英语 |
Funding Project | National Basic Research Program (973 program)[2014CB138601] ; National Natural Science Foundation of China[41576137] ; National Natural Science Foundation of China[31202006] ; China Agriculture Researches System[CARS 47-G10] |
WOS Research Area | Fisheries ; Marine & Freshwater Biology |
WOS Subject | Fisheries ; Marine & Freshwater Biology |
WOS ID | WOS:000442900300062 |
WOS Keyword | NF-KAPPA-B ; TURBOT SCOPHTHALMUS-MAXIMUS ; SALMO-SALAR L. ; ACTIVATED-RECEPTOR-GAMMA ; LIGHT-CHAIN KINASE ; BARRIER FUNCTION ; ATLANTIC SALMON ; INTESTINAL MICROBIOTA ; PPAR-GAMMA ; EPITHELIAL BARRIER |
Publisher | ELSEVIER SCIENCE BV |
Funding Organization | National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Basic Research Program (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System ; China Agriculture Researches System |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ihb.ac.cn/handle/342005/29471 |
Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
Corresponding Author | Zhang, Yanjiao |
Affiliation | 1.Ocean Univ China, Minist Agr, Key Lab Aquaculture Nutr & Feed, Qingdao 266003, Peoples R China 2.Ocean Univ China, Minist Educ, Key Lab Mariculture, Qingdao 266003, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Yang,Chen, Zhichu,Dai, Jihong,et al. The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.[J]. AQUACULTURE,2018,497(1):510-519. |
APA | Liu, Yang.,Chen, Zhichu.,Dai, Jihong.,Yang, Pei.,Hu, Haibin.,...&Mai, Kangsen.(2018).The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L..AQUACULTURE,497(1),510-519. |
MLA | Liu, Yang,et al."The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.".AQUACULTURE 497.1(2018):510-519. |
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