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Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol Check for acetate
Hua, Jianghuan1,2; Han, Jian3; Guo, Yongyong2; Zhou, Bingsheng2
Corresponding AuthorZhou, Bingsheng(bszhou@ihb.ac.cn)
2018-11-15
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume163Pages:289-297
AbstractSynthetic progestins are widely used pharmaceutical agents that have become common contaminants in the aquatic environment. The potential adverse effects of long-term exposure on aquatic wildlife, however, are not fully understood. The aim of this study was to investigate the endocrine disruption in Chinese rare minnow (Gobiocypris rarus) in response to megestrol acetate (MTA) exposure. Newly-hatched Chinese rare minnow larvae were exposed to MTA at a nominal concentration of either 1 ng/L (detected concentrations ranged from 0.18 to 0.93 ng/L) or 10 ng/L (detected concentrations ranged from 4.27 to 9.64 ng/L) for 6 months and the effects on growth, sex steroid hormones, gonadal histology, and steroidogenic genes expression were determined. After 6 months of exposure to a nominal concentration of 10 ng/L MTA, the body weight and condition factors were significantly increased in fish of both sexes. Exposure to a nominal concentration of 10 ng/L MTA significantly reduced plasma concentrations of estradiol and 11-ketotestosterone in female fish while also reducing testosterone and 11-ketotestosterone in male fish. Gonad histology revealed significantly reduced proportions of vitellogenic oocytes in female fish exposed to a nominal concentration of 10 ng/L MTA and induction of atretic follicles in female fish exposed to both nominal concentrations of MTA. The expression of cyp19a1a and cyp17a1 in the gonads was up-regulated in the ovaries while down-regulated in the testes. Our results indicate that MTA can induce endocrine disruption in Chinese rare minnow at the low concentrations found in contaminated environments. This indicates a potentially high ecological risk from MTA to fish populations in MTA-contaminated aquatic environments in China and may also in other regions.
KeywordEndocrine disruption Megestrol acetate Long-term exposure Chinese rare minnow
DOI10.1016/j.ecoenv.2018.07.049
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21277170] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ11] ; Natural Science Foundation of Hubei Province, China[2018CFB324] ; Youth Research Plan of Hubei University of Chinese Medicine[2017ZZX009]
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000443104400035
WOS KeywordTANDEM MASS-SPECTROMETRY ; ZEBRAFISH DANIO-RERIO ; ADVERSELY AFFECT REPRODUCTION ; BINARY-MIXTURES ; SURFACE-WATER ; WASTE-WATER ; DEVELOPMENTAL EXPOSURE ; SYNTHETIC PROGESTINS ; ESTROGENIC ACTIVITY ; FATHEAD MINNOWS
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Natural Science Foundation of Hubei Province, China ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine ; Youth Research Plan of Hubei University of Chinese Medicine
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29449
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, Bingsheng
Affiliation1.Hubei Univ Chinese Med, Sch Basic Med Sci, Wuhan 430065, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250103, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Hua, Jianghuan,Han, Jian,Guo, Yongyong,et al. Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol Check for acetate[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,163:289-297.
APA Hua, Jianghuan,Han, Jian,Guo, Yongyong,&Zhou, Bingsheng.(2018).Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol Check for acetate.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,163,289-297.
MLA Hua, Jianghuan,et al."Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol Check for acetate".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 163(2018):289-297.
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