IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection
Cao, Yongsheng1,2; Wang, Di1; Li, Shaowu1; Xu, Liming1; Zhao, Jingzhuang1; Liu, Hongbai1; Lu, Tongyan1; Zhang, Qiya2
Corresponding AuthorLu, Tongyan(lutongyan@hotmail.com) ; Zhang, Qiya(zhangqy@ihb.ac.cn)
2018-11-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume88Pages:28-36
AbstractMicroRNAs (miRNAs) are a class of regulators essential for numerous biological processes. Infectious hematopoietic necrosis virus (IHNV) is one of the most important viral pathogens in salmon and trout. In this study, the miRNA expression profiles of rainbow trout upon IHNV infection were explored. In total, 392 known miRNAs and 936 novel miRNAs were identified. Twelve known and 13 novel miRNAs were differentially expressed between infected and uninfected fish. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that certain miRNA target genes were associated with biological regulation, the immune system, and signal transduction. In addition, over- and suppressed expression of miR-146a-3p, miR-155-5p, miR-216a-5p, and miR-499b-5p could respectively increase and decrease viral gene expression in cells and viral titers. MiR-146a-3p and miR-216a-5p inhibited the expression of type-I IFN and the Mxl gene induced by IHNV. These results provide preliminary insights into the IHNV-host interactions mediated by miRNAs.
KeywordmicroRNA Rainbow trout IHNV Deep sequencing Functional analysis
DOI10.1016/j.dci.2018.07.004
Funding OrganizationCentral-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System
Indexed BySCI ; SCI
Language英语
Funding ProjectCentral-level Nonprofit Scientific Research Institutes Special Funds[HSY201702M] ; Natural Science Foundation of Heilongjiang Province of China[C2018073] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2017FB03] ; China Postdoctoral Science Foundation[2016M602395] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2017HY-ZD1009] ; Earmarked Fund for China Agriculture Research System[CARS-46]
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS IDWOS:000443668600004
WOS KeywordGROUPER EPINEPHELUS-COIOIDES ; SIGNALING PATHWAY ; VHSV INFECTION ; MIIUY CROAKER ; TELEOST FISH ; APOPTOSIS ; PROFILE ; CELLS ; RNA ; PROLIFERATION
PublisherELSEVIER SCI LTD
Funding OrganizationCentral-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Central-level Nonprofit Scientific Research Institutes Special Funds ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; Natural Science Foundation of Heilongjiang Province of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Central Public-interest Scientific Institution Basal Research Fund, CAFS ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29411
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorLu, Tongyan; Zhang, Qiya
Affiliation1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Dept Aquaculture, Lab Fish Dis, Songfa St 43, Harbin 150070, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Cao, Yongsheng,Wang, Di,Li, Shaowu,et al. Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,88:28-36.
APA Cao, Yongsheng.,Wang, Di.,Li, Shaowu.,Xu, Liming.,Zhao, Jingzhuang.,...&Zhang, Qiya.(2018).Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,88,28-36.
MLA Cao, Yongsheng,et al."Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 88(2018):28-36.
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