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Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae
Xing, Xiumei1; Kang, Jianmeng1; Qiu, Jiahuang; Zhong, Xiali1; Shi, Xiongjie2; Zhou, Bingsheng3; Wei, Yanhong1
Corresponding AuthorWei, Yanhong(weiyh9@mail.sysu.edu.cn)
2018-10-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume203Pages:19-27
AbstractPolybrominated diphenyl ethers (PBDEs) are persistent flame retardants ubiquitously existing in various environment matrices. In spite of a recent reduction in use according to the phase-out policy, high levels of PBDEs are still found in both environmental and biological samples due to their persistent property and large-scale production over a long history. Developmental toxicity is a major health concern of PBDEs. However, the impact of PBDE exposure on vascular development remains poorly understood. In this study, we investigated the effect of low concentrations of 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), a predominant PBDE congener, in environmental matrices and biota, on early vascular development using zebrafish. Zebrafish embryos were continuously exposed to waterborne BDE-47 at 0.06, 0.2, 0.6 mu M starting from 2 h post-fertilization (hpf). Fluorescent images of vasculatures in Tg(kdrl:eGFP) zebrafish were acquired using a confocal microscope. The results indicated that BDE-47 exposure had no effect on hatching rate, survival, body weight, body length or heart rate in the early stage within 72 hpf, whereas zebrafish exposed to BDE-47 exhibited impairments in the growth of multiple types of blood vessels. The percentage of completed intersegmental vessels (ISV) at 30 hpf decreased in embryos treated with BDE-47 in a dose-dependent fashion. BDE-47 exposure led to a slight decrease in the growth of common cardinal vein (CCV), while dramatically hindered CCV remodeling process reflected by the larger CCV area and wider ventral diameter. BDE-47 exposure significantly reduced sub-intestinal vessels (SIV) area as well as the vascularized yolk area in zebrafish larvae at 72 hpf. In addition, the expression of genes related to vascular growth and remodeling was markedly suppressed in BDE-47-exposed zebrafish. These findings demonstrate the adverse effects of BDE-47 on early vascular development, and confirm the vascular toxicity of PBDEs in vivo. The results indicate that developing vasculature in zebrafish is sensitive to BDE-47 exposure, and may serve as a powerful tool for the assessment of early exposure to PBDEs.
KeywordZebrafish Polybrominated diphenyl ethers Brominated flame retardants Early exposure Developmental toxicity Vascular toxicity
DOI10.1016/j.aquatox.2018.07.012
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21777199] ; National Natural Science Foundation of China[81402715] ; National Key R & D program of China[2017YFC1600205] ; 100 Top Talents Program of Sun Yat-sen University
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000446147500003
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; EMBRYONIC EXPOSURE ; FLAME-RETARDANTS ; DANIO-RERIO ; BREAST-MILK ; VEGF ; ANGIOGENESIS ; LARVAE ; PBDES ; ENVIRONMENT
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; National Key R & D program of China ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University ; 100 Top Talents Program of Sun Yat-sen University
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29290
Collection水环境工程研究中心_期刊论文
Corresponding AuthorWei, Yanhong
Affiliation1.Sun Yat Sen Univ, Sch Publ Hlth, Dept Toxicol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China
2.Wuhan Univ, Inst Adv Studies, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Xing, Xiumei,Kang, Jianmeng,Qiu, Jiahuang,et al. Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae[J]. AQUATIC TOXICOLOGY,2018,203:19-27.
APA Xing, Xiumei.,Kang, Jianmeng.,Qiu, Jiahuang.,Zhong, Xiali.,Shi, Xiongjie.,...&Wei, Yanhong.(2018).Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae.AQUATIC TOXICOLOGY,203,19-27.
MLA Xing, Xiumei,et al."Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae".AQUATIC TOXICOLOGY 203(2018):19-27.
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