IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury
Vozdek, Roman1,2; Long, Yong1,2,3; Ma, Dengke K.1,2
Corresponding AuthorMa, Dengke K.(dengke.ma@ucsf.edu)
2018-10-02
Source PublicationSCIENCE SIGNALING
ISSN1945-0877
Volume11Issue:550Pages:12
AbstractInadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular matrix (ECM) remodeling, cellular metabolic adaptation, and cancer cell metastasis. To discover new pathways through which cells respond to hypoxia, we performed a large-scale forward genetic screen in Caenorhabditis elegans and identified a previously uncharacterized receptor tyrosine kinase named HIR-1. Loss of function in hir-1 phenocopied the impaired ECM integrity associated with hypoxia or deficiency in the oxygen-dependent dual oxidase, heme peroxidases, or cuticular collagens involved in ECM homeostasis. Genetic suppressor screens identified NHR-49 and MDT-15 as transcriptional regulators downstream of HIR-1. Furthermore, hir-1 mutants showed defects in adapting to and recovering from prolonged severe hypoxia. We propose that C. elegans HIR-1 coordinates hypoxia-inducible factor-independent responses to hypoxia and hypoxia-associated ECM remodeling through mechanisms that are likely conserved in other organisms.
DOI10.1126/scisignal.aat0138
Funding OrganizationNIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship
Indexed BySCI ; SCI
Language英语
Funding ProjectNIH[R01GM117461] ; NIH[R00HL116654] ; American Diabetes Association grant[1-16-IBS-197] ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000446086600002
WOS KeywordNEMATODE CAENORHABDITIS-ELEGANS ; C-ELEGANS ; OXYGEN DEPRIVATION ; STRESS-RESPONSE ; GENE ONTOLOGY ; GROWTH-FACTOR ; HYDROXYLASE ; CUTICLE ; CANCER ; PROLYL
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Funding OrganizationNIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; NIH ; NIH ; NIH ; NIH ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; American Diabetes Association grant ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Pew Scholar Award ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Alfred P. Sloan Foundation Fellowship ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Packard Fellowship in Science and Engineering ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom start-up grant ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship ; Larry L. Hillblom fellowship
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29281
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorMa, Dengke K.
Affiliation1.Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA
2.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Vozdek, Roman,Long, Yong,Ma, Dengke K.. The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury[J]. SCIENCE SIGNALING,2018,11(550):12.
APA Vozdek, Roman,Long, Yong,&Ma, Dengke K..(2018).The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.SCIENCE SIGNALING,11(550),12.
MLA Vozdek, Roman,et al."The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury".SCIENCE SIGNALING 11.550(2018):12.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Vozdek, Roman]'s Articles
[Long, Yong]'s Articles
[Ma, Dengke K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Vozdek, Roman]'s Articles
[Long, Yong]'s Articles
[Ma, Dengke K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Vozdek, Roman]'s Articles
[Long, Yong]'s Articles
[Ma, Dengke K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.