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题名: Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda
作者: Sun Yanhong1, 2; Li Qing1; Wang Guiying1; Zhu Dongmei1; Chen Jian1; Li Pei1; Tong Jingou2
关键词: Myostatin-1 (MSTN-1) ; single nucleotide polymorphisms ( SNPs) ; Ancherythroculter nigrocauda ; growth traits ; association analysis
刊名: CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
发表日期: 2017-05-01
DOI: 10.1007/s00343-017-5317-0
卷: 35, 期:3, 页:597-602
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Limnology ; Oceanography
研究领域[WOS]: Marine & Freshwater Biology ; Oceanography
英文摘要: Myostatin (MSTN) is a member of the transforming growth factor-beta gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an economically important freshwater fish, were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2, including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T > C SNP locus was significantly associated with total length (TL), body length (BL), body height (BH) and body weight (BW) in 6- and 18-month-old populations, while the g.1289G > A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T > C and g.1289G > A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda.
关键词[WOS]: SALMON SALMO-SALAR ; MARKER ASSISTED SELECTION ; MSTN GENE ; IDENTIFICATION ; REGION ; SNP ; WEIGHT ; CATTLE
语种: 英语
项目资助者: National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; Wuhan Chenguang Project for Young Scholars(201372304010832)
WOS记录号: WOS:000399168400014
ISSN号: 0254-4059
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/29210
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Wuhan Aquaculture Sci Res Inst, Wuhan 430207, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
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