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Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda
Sun Yanhong1,2; Li Qing1; Wang Guiying1; Zhu Dongmei1; Chen Jian1; Li Pei1; Tong Jingou2
2017-05-01
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
Volume35Issue:3Pages:597-602
AbstractMyostatin (MSTN) is a member of the transforming growth factor-beta gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an economically important freshwater fish, were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2, including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T > C SNP locus was significantly associated with total length (TL), body length (BL), body height (BH) and body weight (BW) in 6- and 18-month-old populations, while the g.1289G > A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T > C and g.1289G > A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda.
SubtypeArticle
KeywordMyostatin-1 (Mstn-1) Single Nucleotide Polymorphisms ( Snps) Ancherythroculter Nigrocauda Growth Traits Association Analysis
DOI10.1007/s00343-017-5317-0
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Indexed BySCI
Funding OrganizationNational Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; Wuhan Chenguang Project for Young Scholars(201372304010832)
Language英语
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS SubjectLimnology ; Oceanography
WOS KeywordSALMON SALMO-SALAR ; MARKER ASSISTED SELECTION ; MSTN GENE ; IDENTIFICATION ; REGION ; SNP ; WEIGHT ; CATTLE
WOS IDWOS:000399168400014
Funding OrganizationNational Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Young Scientists of China(31402296) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; National Science Foundation for Post-Doctoral Scientists of China(2014M562077) ; Wuhan Chenguang Project for Young Scholars(201372304010832) ; Wuhan Chenguang Project for Young Scholars(201372304010832)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29210
Collection鱼类生物学及渔业生物技术研究中心
Affiliation1.Wuhan Aquaculture Sci Res Inst, Wuhan 430207, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Sun Yanhong,Li Qing,Wang Guiying,et al. Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2017,35(3):597-602.
APA Sun Yanhong.,Li Qing.,Wang Guiying.,Zhu Dongmei.,Chen Jian.,...&Tong Jingou.(2017).Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,35(3),597-602.
MLA Sun Yanhong,et al."Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 35.3(2017):597-602.
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