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题名: Quantitative analysis of glutathione and cysteine S-conjugates of microcystin-LR in the liver, kidney and muscle of common carp (Cyprinus carpio) in Lake Taihu
作者: Wu, Laiyan1, 2; Wang, Songbo1, 2; Tao, Min3; Xie, Ping4; Chen, Jun4
关键词: common carp ; kidney ; liver ; MC-LR-Cys ; MC-LR-GSH
刊名: JOURNAL OF WATER AND HEALTH
发表日期: 2017-04-01
DOI: 10.2166/wh.2016.139
卷: 15, 期:2, 页:300-307
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health ; Microbiology ; Water Resources
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Microbiology ; Water Resources
英文摘要: Tissue distribution of microcystin (MC)-LR-GSH, MC-LR-Cys and MC-LR of omnivorous fish in Lake Taihu was investigated. MC-LR and MC-LR-Cys were detected in liver, kidney and muscle. The concentration of MC-LR in liver and kidney was 0.052 mu g g(-1) DW and 0.067 mu g g(-1) DW, respectively. MC-LR-Cys appeared to be an important metabolite with average contents of 1.104 mu g g(-1) DW and 0.724 mu g g(-1) DW in liver and kidney, and the MC-LR-Cys/MC-LR ratio in liver and kidney reaching as high as 21.4 and 10.8. High MC-LR-Cys/MC-LR ratio and a significant correlation between MC-LR-Cys and MC-LR concentration in liver, suggest that liver is more active in detoxification of MC-LR by formation of MC-LR-Cys for omnivorous fish. Furthermore, there might be a balance between the accumulation and depuration/metabolism of MC-LR-Cys in kidney. The MC-LR-Cys can be formed in kidney directly, or transported from liver or other tissues, while the MC-LR-Cys in kidney might be dissociated to MC-LR or excreted. Although MC-LR and its metabolites were scarcely detected in muscle, it is necessary to investigate the distribution of toxic metabolites in edible muscle.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; CYANOBACTERIAL TOXINS ; FISH ; DETOXIFICATION ; DETOXICATION ; METABOLITES ; NOBILIS ; CHINA ; GSH ; RR
语种: 英语
项目资助者: State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; National Natural Science Foundations of China(21307164 ; Study Abroad for CSC Sponsored Chinese Citizen ; Academic Research Abroad from South-Central University for Nationalities Sponsored Outstanding Young Teacher ; 31200361)
WOS记录号: WOS:000399317700013
ISSN号: 1477-8920
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/29184
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.South Cent Univ Nationalities, Coll Resources & Environm Sci, Key Lab Catalysis & Mat Sci State Ethn Affairs Co, Wuhan 430074, Peoples R China
2.South Cent Univ Nationalities, Coll Resources & Environm Sci, Minist Educ, Wuhan 430074, Peoples R China
3.Neijiang Normal Univ, Life Sci Coll, Neijiang 641000, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7, Wuhan 430072, Peoples R China
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