IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians
Gan, Zhen1,2; Yang, Yue Cong1,2; Chen, Shan Nan1; Hou, Jing1,2; Laghari, Zubair Ahmed1; Huang, Bei1; Li, Nan1; Nie, Pin1,3,4
Corresponding AuthorNie, Pin(pinnie@ihb.ac.cn)
2018-12-01
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume201Issue:11Pages:3329-3342
AbstractIn vertebrates, intron-containing and intronless type I IFN genes have recently been reported in amphibian model species Xenopus tropicalis and X. laevis. However, whether intronless type I IFNs in amphibians are the ancestral genes of type I IFNs in amniotes or just represent the independent divergence in amphibians is unknown or even uninvestigated. In this study, both introncontaining and intronless type I IFN genes, as well as their receptor genes, were identified in the Tibetan frog Nanorana parkeri. The evidence obtained from homology, synteny, phylogeny, and divergence time showed that intronless type I IFN genes in N. parkeri and in Xenopus might have arisen from two independent retroposition events occurred in these two lineages, and the retrotransposition causing the generation of intronless type I IFN genes in amniotes is another independent event beyond the two in amphibians. It can then be proposed that intronless type I IFNs in N. parkeri and Xenopus may not be the ancestral genes of intronless type I IFNs in amniotes but may just represent two independent bifurcations in the amphibian lineage. Furthermore, both intronless and intron-containing type I IFNs in N. parkeri showed strong ability in inducing the expression of IFN-stimulated genes and the strong antiviral activity against frog virus 3. The present study thus provides the evolutionary evidence to support the independent retroposition hypothesis for the occurrence of intronless type I IFN genes in amphibians and contributes to a functional understanding of type I IFNs in this group of vertebrates.
DOI10.4049/jimmunol.1800553
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31230075] ; China Agriculture Research System[CARS-46] ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000450523800020
WOS KeywordHUMAN INTERFERON-BETA ; VIRUS 3 RANAVIRUS ; XENOPUS-LAEVIS ; CRYSTAL-STRUCTURE ; DIVERGENCE TIMES ; STIMULATED GENES ; EVOLUTION ; ZEBRAFISH ; RECEPTOR ; EXPRESSION
PublisherAMER ASSOC IMMUNOLOGISTS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29093
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, Pin
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
4.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Gan, Zhen,Yang, Yue Cong,Chen, Shan Nan,et al. Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians[J]. JOURNAL OF IMMUNOLOGY,2018,201(11):3329-3342.
APA Gan, Zhen.,Yang, Yue Cong.,Chen, Shan Nan.,Hou, Jing.,Laghari, Zubair Ahmed.,...&Nie, Pin.(2018).Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians.JOURNAL OF IMMUNOLOGY,201(11),3329-3342.
MLA Gan, Zhen,et al."Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians".JOURNAL OF IMMUNOLOGY 201.11(2018):3329-3342.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gan, Zhen]'s Articles
[Yang, Yue Cong]'s Articles
[Chen, Shan Nan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gan, Zhen]'s Articles
[Yang, Yue Cong]'s Articles
[Chen, Shan Nan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gan, Zhen]'s Articles
[Yang, Yue Cong]'s Articles
[Chen, Shan Nan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.