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Genome-wide identification of ATP-binding cassette (ABC) transporters and conservation of their xenobiotic transporter function in the monogonont rotifer (Brachionus koreanus)
Jeong, Chang-Bum1,2; Kim, Hui-Su1; Kang, Hye-Min1; Lee, Young Hwan1; Zhou, Bingsheng3; Choe, Joonho4; Lee, Jae-Seong1
2017-03-01
Source PublicationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
ISSN1744-117X
Volume21Pages:17-26
AbstractThe ATP-binding cassette (ABC) transporter family is one of the largest gene family in animals, and members of this family are known to be involved in various biological processes due to their ability to transport a wide range of substrates across membranes using ATP cleavage-derived energy. We identified 61 ABC transporters in the genome of the monogonont rotifer Brachionus koreanus, and classified these into eight distinct subfamilies (A-H) by phylogenetic analysis. ABC transporters in the rotifer B. koreanus are comprised of 11 ABCA genes, 19 ABCB genes, 14 ABCC genes, 3 ABCD genes, 1 ABCE gene, 3 ABCF genes, 8 ABCG genes, and 2 ABCH genes. Extensive gene duplication and loss events in synteny were observed in several subfamilies. In particular, massive gene duplications of P-glycoproteins (P-gps), multidrug resistance proteins (MRPs), and Bk-Abcg-like proteins were observed. The ability of these B. koreanus proteins to function as multixenobiotic resistance (MXR) ABC transporters was validated using specific fluorescence substrates/inhibitors. The ABC transporter superfamily members identified in this study will be useful in future toxicological studies, and will facilitate comparative studies of the evolution of the ABC transporter superfamily in invertebrates. (C) 2016 Elsevier Inc. All rights reserved.
SubtypeArticle
KeywordAbc Transporter Multixenobiotic Resistance Mxr Rotifer Brachionus Koreanus
DOI10.1016/j.cbd.2016.10.003
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationMarine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350)
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Genetics & Heredity
WOS SubjectBiochemistry & Molecular Biology ; Genetics & Heredity
WOS KeywordMULTIDRUG-RESISTANCE PROTEINS ; SEA-URCHIN EMBRYOS ; P-GLYCOPROTEIN ; GENE FAMILY ; DROSOPHILA-MELANOGASTER ; CAENORHABDITIS-ELEGANS ; SUPERFAMILY ; CANCER ; INSECTICIDE ; GLUTATHIONE
WOS IDWOS:000395224100003
Funding OrganizationMarine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea(PJT200620) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350) ; Korea Polar Ocean Development - Ministry of Oceans and Fisheries, Korea(PE16350)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/29036
Collection水环境工程研究中心
Affiliation1.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea
2.Hanyang Univ, Coll Nat Sci, Dept Chem, Seoul 04763, South Korea
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
4.Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon 34141, South Korea
Recommended Citation
GB/T 7714
Jeong, Chang-Bum,Kim, Hui-Su,Kang, Hye-Min,et al. Genome-wide identification of ATP-binding cassette (ABC) transporters and conservation of their xenobiotic transporter function in the monogonont rotifer (Brachionus koreanus)[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2017,21:17-26.
APA Jeong, Chang-Bum.,Kim, Hui-Su.,Kang, Hye-Min.,Lee, Young Hwan.,Zhou, Bingsheng.,...&Lee, Jae-Seong.(2017).Genome-wide identification of ATP-binding cassette (ABC) transporters and conservation of their xenobiotic transporter function in the monogonont rotifer (Brachionus koreanus).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,21,17-26.
MLA Jeong, Chang-Bum,et al."Genome-wide identification of ATP-binding cassette (ABC) transporters and conservation of their xenobiotic transporter function in the monogonont rotifer (Brachionus koreanus)".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 21(2017):17-26.
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