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题名: Androgen signaling regulates the transcription of anti-Mullerian hormone via synergy with SRY-related protein SOX9A
作者: Zhai, Gang1; Shu, Tingting1, 2; Xia, Yuguo3; Jin, Xia1; He, Jiangyan1; Yin, Zhan1
关键词: Zebrafish ; Androgen signaling ; SOX9A ; Transcription ; amh
刊名: SCIENCE BULLETIN
发表日期: 2017-02-15
DOI: 10.1016/j.scib.2017.01.007
卷: 62, 期:3, 页:197-203
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Anti-Mullerian hormone (amh) is one of the earliest functional genes expressed during testicular differentiation. It has been suggested that androgen signaling regulates critical genes for the differentiation and development of the testis. To elucidate the exact regulatory mechanisms involved in amh transcription mediated by androgen signaling, androgen signaling was manipulated in zebrafish by cytochrome P450 17a1 (cyp17a1) knockout and Flutamide treatment. In cyp17a1-deficient and Flutamide-treated testes, up-regulated sry-box9a (sox9a) and down-regulated amh were observed. Moreover, a physical association of the zebrafish androgen receptor (AR) and SOX9A was found. The interaction between AR and SOX9A was mediated via the DNA binding domain (DBD) of AR and the transactivation domain (TA) of SOX9A, and was further enhanced by 5-alpha dihydrotestosterone (DHT), one of the most potent androgens. Intriguingly, together with SOX9A, androgen signaling synergistically promoted amh transcription, mainly through the proximal 1 kb of the amh promoter region. Taken together, our data demonstrate a critical mechanism underlying the direct synergy of androgen signaling and SOX9A in the regulation of amh transcription. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
关键词[WOS]: GENE-EXPRESSION ; COMPLEMENTARY-DNA ; PROSTATE-CANCER ; RECEPTOR ; ZEBRAFISH ; RAT ; SPERMATOGENESIS ; EXPOSURE ; CLONING ; TESTIS
语种: 英语
项目资助者: National Natural Science Foundation of China(31501857 ; National Basic Research Program of China(2014CB138602) ; 31530077)
WOS记录号: WOS:000396758000007
ISSN号: 2095-9273
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/28968
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou 510380, Guangdong, Peoples R China
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