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题名: Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae
作者: Xiong, Xiaoqin1, 2; Luo, Si1, 2; Wu, Benli3; Wang, Jianwei1
关键词: dimethyl sulfoxide ; developmental toxicity ; stress protein responses ; rare minnow ; zebrafish
刊名: ZEBRAFISH
发表日期: 2017-02-01
DOI: 10.1089/zeb.2016.1287
卷: 14, 期:1, 页:60-68
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Developmental Biology ; Zoology
研究领域[WOS]: Developmental Biology ; Zoology
英文摘要: Dimethyl sulfoxide ( DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish ( Danio rerio) with two tests were compared in the early life stage. In the first test, fertilized eggs were exposed to 0%, 0.0001%, 0.001%, 0.01%, 0.1%, 1.0%, 1.5%, and 2.0% v/v of DMSO until 3 days post hatching. In the second test, larvae from 0 to 8 d were exposed to 2% DMSO until 4 days. Our results showed that DMSO was toxic to rare minnow and zebrafish on multiple indexes, and the no-observed-effect concentrations of DMSO in both species were 1.0% and 0.001% for developmental toxicity analysis and stress protein analysis, respectively. Furthermore, rare minnow larvae were more sensitive than zebrafish to DMSO for spinal malformation. The sensitive period for induction of spinal malformation by DMSO was 0-7 d after hatch (dah) for rare minnow and 0-4 dah for zebrafish. Together, these results will provide support to the use of DMSO in ecotoxicological studies using rare minnow and will contribute to a better understanding of the toxicity of DMSO.
关键词[WOS]: DANIO-RERIO EMBRYOS ; GOBIOCYPRIS-RARUS ; LARVAL DEVELOPMENT ; CARRIER SOLVENTS ; OXIDATIVE STRESS ; FATHEAD MINNOW ; DMSO ; ASSAY ; NEUROTOXICITY ; EXPOSURE
语种: 英语
项目资助者: National High-Tech Research and Development Projects(2012AA06A302-4)
WOS记录号: WOS:000392882200008
ISSN号: 1545-8547
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/28937
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Anhui Acad Agr Sci, Fisheries Res Inst, Hefei, Peoples R China
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