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Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition
Luo, Qiang1,2; Wang, Zhaokai3; Chen, Huibin3; Fang, Hui3; Xie, Shouqi2; Qian, Xueqiao1; Lin, Xiangzhi3
2016-08-16
Source PublicationCHEMISTRYSELECT
ISSN2365-6549
Volume1Issue:13Pages:3909-3913
AbstractNatural products (NP), especially medicinal plants, have been used worldwide to treat numerous diseases for thousands of years. However, drug discovery focus has been moving away from identifying lead compounds from complex mixtures of crude NP because this approach is technically difficult and inefficient. We here present a quick, accurate and practical method for screening leads targeting a nuclear receptor from NP mixtures. Using the method, we rapidly identified erythrotriol as a new lead compound from medicinal plant Hibiscus syriacus L. targeting RXR alpha for treating cancer with less side effects. This method can efficiently and profitably screen lead compounds targeting nuclear receptors and may reinvigorate interest in NP as sources of pharmaceutical agents.
SubtypeArticle
KeywordNatural Products Nuclear Receptor Rxr Alpha Erythrotriol Tumor
DOI10.1002/slct.201600907
WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
Funding OrganizationRegional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; National Natural Science Foundation of China(31401564) ; National Natural Science Foundation of China(31401564) ; Marine High-technology Industry of the Fujian Province([2013]30 ; Marine High-technology Industry of the Fujian Province([2013]30 ; [2014]23) ; [2014]23) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; National Natural Science Foundation of China(31401564) ; National Natural Science Foundation of China(31401564) ; Marine High-technology Industry of the Fujian Province([2013]30 ; Marine High-technology Industry of the Fujian Province([2013]30 ; [2014]23) ; [2014]23)
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS KeywordT-CELL LYMPHOMA ; RXR-ALPHA ; DISCOVERY ; BEXAROTENE ; PARTNERS ; CANCER ; SUPERFAMILY ; MODULATORS ; CHEMISTRY ; HONOKIOL
WOS IDWOS:000392302300075
Funding OrganizationRegional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; National Natural Science Foundation of China(31401564) ; National Natural Science Foundation of China(31401564) ; Marine High-technology Industry of the Fujian Province([2013]30 ; Marine High-technology Industry of the Fujian Province([2013]30 ; [2014]23) ; [2014]23) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; Regional Demonstration of Marine Economy Innovative Development Project(12PYY001SF08) ; National Natural Science Foundation of China(31401564) ; National Natural Science Foundation of China(31401564) ; Marine High-technology Industry of the Fujian Province([2013]30 ; Marine High-technology Industry of the Fujian Province([2013]30 ; [2014]23) ; [2014]23)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28857
Collection淡水生态学研究中心
Affiliation1.Guangdong Haid Grp Co Ltd, Anim Husb & Fisheries Res Ctr, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
3.State Ocean Adm, Inst Oceanog 3, Engn Res Ctr Marine Biol Resource Comprehens Util, Xiamen, Peoples R China
Recommended Citation
GB/T 7714
Luo, Qiang,Wang, Zhaokai,Chen, Huibin,et al. Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition[J]. CHEMISTRYSELECT,2016,1(13):3909-3913.
APA Luo, Qiang.,Wang, Zhaokai.,Chen, Huibin.,Fang, Hui.,Xie, Shouqi.,...&Lin, Xiangzhi.(2016).Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition.CHEMISTRYSELECT,1(13),3909-3913.
MLA Luo, Qiang,et al."Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition".CHEMISTRYSELECT 1.13(2016):3909-3913.
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