IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7
Lu, Long-Feng1,2; Li, Shun1,2; Wang, Zhao-Xi1,3; Liu, Shu-Bo1,3; Chen, Dan-Dan1,4; Zhang, Yong-An1,2,4
Corresponding AuthorZhang, Yong-An(yonganzhang@mail.hzau.edu.cn)
2019
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume202Issue:1Pages:119-130
AbstractViral infection activates the transcription factor IFN regulatory factor 7 (IRF7), which plays a critical role in the induction of IFNs and innate antiviral immune response. How virus-induced IFN signaling is controlled in fish is not fully understood. In this study, we demonstrate that N-myc downstream-regulated gene 1a (NDRG1a) in zebrafish plays a role as a negative regulator for virus-triggered IFN induction. First, the activation of the IFN promoter stimulated by the polyinosinic-polycytidylic acid or spring viremia of carp virus was decreased by the overexpression of NDRG1a. Second, NDRG1a interacted with IRF7 and blocked the IFN transcription activated by IRF7. Furthermore, NDRG1a was phosphorylated by TANK-binding kinase 1 (TBK1) and promoted the K48-linked ubiquitination and degradation of IRF7. Finally, the overexpression of NDRG1a blunted the transcription of several IFN-stimulated genes, resulting in the host cells becoming susceptible to spring viremia of carp virus infection. Our findings suggest that fish NDRG1a negatively regulates the cellular antiviral response by targeting IRF7 for ubiquitination and degradation, providing insights into the novel role of NDRG1a on the innate antiviral immune response in fish.
DOI10.4049/jimmunol.1800490
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31725026] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000454422600013
WOS KeywordINTERFERON ANTIVIRAL RESPONSE ; PATTERN-RECOGNITION RECEPTORS ; INNATE IMMUNE-RESPONSE ; NF-KAPPA-B ; RIG-I ; METASTASIS SUPPRESSOR ; ADAPTER PROTEIN ; IFN-PHI-1 PRODUCTION ; MEDIATED ACTIVATION ; SIGNALING PROTEIN
PublisherAMER ASSOC IMMUNOLOGISTS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28830
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorZhang, Yong-An
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430070, Hubei, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Lu, Long-Feng,Li, Shun,Wang, Zhao-Xi,et al. Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7[J]. JOURNAL OF IMMUNOLOGY,2019,202(1):119-130.
APA Lu, Long-Feng,Li, Shun,Wang, Zhao-Xi,Liu, Shu-Bo,Chen, Dan-Dan,&Zhang, Yong-An.(2019).Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7.JOURNAL OF IMMUNOLOGY,202(1),119-130.
MLA Lu, Long-Feng,et al."Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7".JOURNAL OF IMMUNOLOGY 202.1(2019):119-130.
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