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题名: Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates
作者: Gan, Zhen1, 2; Chen, Shan Nan1; Huang, Bei3; Hou, Jing1, 2; Nie, Pin1
关键词: Type I IFN ; Intronless type I IFN ; Intron-containing type I IFN ; Retroposition event ; Xenopus tropicalis
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2017-02-01
DOI: 10.1016/j.dci.2016.10.007
卷: 67, 页:166-176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
英文摘要: Type I IFNs are considered to be the core IFN species in vertebrates because of their predominant antiviral effects. But, a puzzling question remains to be answered, as to how intronless type I IFN genes in amniotes might have evolved from intron-containing type I IFN genes in fish and amphibians. In this study, intronless and intron-containing type I IFNs were found in the amphibian model, Xenopus tropicalis, with a total of sixteen and five genes, respectively. The intronless IFNs can be divided into three subgroups, and the intron-containing ones into two subgroups, implying that a retroposition event might have occurred in amphibians, resulting in the generation of intronless type I IFN genes. Two models were tentatively proposed to explain the evolution of type I IFNs in vertebrates: in model A, fish should possess the most primitive multi-exon-containing type I IFNs, and intronless type I IFN genes in amphibians are the ancestor of modern intronless type I IFNs in amniotes; in model B, intronless type I IFN genes in X. tropicalis may just represent an independent bifurcation in this species or probably in amphibians, and intronless type I IFN genes in amniotes may have arisen from another retroposition event occurred in a transition period even when reptiles were diverged from amphibians. It is considered that the model B can reflect the current knowledge on the occurrence of intronless and intron-containing type I IFN genes in vertebrate lineages. This study thus contributes to a better understanding of the origin and evolution of type I IFNs in vertebrates, and of the occurrence of intronless I IFNs in higher vertebrates. (C) 2016 Elsevier Ltd. All rights reserved.
关键词[WOS]: HUMAN INTERFERON-BETA ; JAK ; IDENTIFICATION ; RECEPTORS ; INDUCTION ; INFECTION ; CYTOKINES ; EFFECTORS ; DISTINCT ; PATHWAY
语种: 英语
项目资助者: National Natural Science Foundation of China(31230075 ; 31320103913)
WOS记录号: WOS:000390071200016
ISSN号: 0145-305X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/28768
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China
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