IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Secretogranin-II plays a critical role in zebrafish neurovascular modeling
Tao, Binbin1,2; Hu, Hongling1,2; Mitchell, Kimberly3; Chen, Ji1; Jia, Haibo4; Zhu, Zuoyan1; Trudeau, Vance L.3; Hu, Wei1
Corresponding AuthorTrudeau, Vance L.(trudeauv@uottawa.ca) ; Hu, Wei(huwei@ihb.ac.cn)
2018-10-01
Source PublicationJOURNAL OF MOLECULAR CELL BIOLOGY
ISSN1674-2788
Volume10Issue:5Pages:388-401
AbstractSecretoneurin (SN) is a neuropeptide derived from specific proteolytic processing of the precursor secretogranin II (SgII). In zebrafish and other teleosts, there are two paralogs named sgIIa and sgIIb. Our results showed that neurons expressing sgIIb were aligned with central arteries in the hindbrain, demonstrating a close neurovascular association. Both sgIIb(-/-) and sgIIa(-/-)/sgIIb(-/-) mutant embryos were defective in hindbrain central artery development due to impairment of migration and proliferation of central artery cells. Further study revealed that sgIIb is non-cell autonomous and required for central artery development. Hindbrain arterial and venous network identities were not affected in sgIIb(-/-) mutant embryos, and the mRNA levels of Notch and VEGF pathway-related genes were not altered. However, the activation of MAPK and PI3K/AKT pathways was inhibited in sgIIb(-/-) mutant embryos. Reactivation of MAPK or PI3K/AKT in endothelial cells could partially rescue the central artery developmental defects in the sgIIb mutants. This study provides the first in vivo evidence that sgIIb plays a critical role in neurovascular modeling of the hindbrain. Targeting the SgII system may, therefore, represent a new avenue for the treatment of vascular defects in the central nervous system.
KeywordSecretogranin-II secretoneurin TALENs neurovascular zebrafish
DOI10.1093/jmcb/mjy027
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31325026] ; National Natural Science Foundation of China[31721005] ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000455315700003
WOS KeywordBLOOD-VESSELS ; SECRETONEURIN ; ANGIOGENESIS ; NEUROPEPTIDE ; MECHANISMS ; CANCER ; NOTCH ; RAT ; GRIDLOCK ; RECEPTOR
PublisherOXFORD UNIV PRESS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28700
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorTrudeau, Vance L.; Hu, Wei
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
3.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada
4.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Tao, Binbin,Hu, Hongling,Mitchell, Kimberly,et al. Secretogranin-II plays a critical role in zebrafish neurovascular modeling[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2018,10(5):388-401.
APA Tao, Binbin.,Hu, Hongling.,Mitchell, Kimberly.,Chen, Ji.,Jia, Haibo.,...&Hu, Wei.(2018).Secretogranin-II plays a critical role in zebrafish neurovascular modeling.JOURNAL OF MOLECULAR CELL BIOLOGY,10(5),388-401.
MLA Tao, Binbin,et al."Secretogranin-II plays a critical role in zebrafish neurovascular modeling".JOURNAL OF MOLECULAR CELL BIOLOGY 10.5(2018):388-401.
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