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TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure
Chen, Lianguo1; Hu, Chenyan2; Guo, Yongyong1; Shi, Qipeng1; Zhou, Bingsheng1
Corresponding AuthorChen, Lianguo(lchenam@ihb.ac.cn)
2019-02-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume217Pages:732-741
AbstractTitanium dioxide (TiO2) nanoparticles and bisphenol A (BPA) in aquatic environments interact reciprocally to enhance the maternal transfer of pollutants to offspring, thus varying the innate toxicities during early embryonic development. However, it remains unexplored regarding the molecular mechanisms of developmental toxicity in offspring after parental coexposure. In the present study, adult zebrafish were exposed to TiO2 nanoparticles (100 mu g/L), BPA (20 mu g/L) or their binary mixture for four months. Then, eggs of F1 generation were collected and reared in clean water until 5 days post-fertilization. In characteristic of larval survival and growth, parental coexposure to TiO2 particles and BPA caused a severer inhibition of F1 offspring larvae compared with single exposure. Mechanistic investigation by shotgun proteomics found that development of larval offspring from coexposed parents was impaired through a distinct mode of toxicity, that is, specifically altering the activity of phagosome and lysosome. Single exposure of adult zebrafish to TiO2 mainly affected insulin-responsive compartment; and BPA parental exposure mainly affected carbohydrate metabolism and calcium signaling of larval offspring. Furthermore, considering the tight regulation of sex hormones in the expression of vitellogenin (VTG), addition of nanoparticles during parental exposure led to inconsistencies between VTG induction and endogenous levels of sex hormones (estradiol and testosterone) in F1 offspring fish. This implied that transfer of nanoparticles to offspring larvae may change the availability of hormonal molecules and BPA at target tissues. Overall, current results provided mechanistic clues into the multigenerational developmental toxicity by parental coexposure to TiO2 particles and BPA. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordParental combined exposure TiO2 and BPA mixture Developmental toxicity Phagolysosome Sex hormones
DOI10.1016/j.chemosphere.2018.11.052
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21577168] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ11]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000456223500080
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; MEDAKA ORYZIAS-MELASTIGMA ; BISPHENOL-A ; ENDOCRINE DISRUPTION ; MARINE BIVALVE ; WEB SERVER ; TOXICITY ; EXPOSURE ; NANO-TIO2 ; BIOCONCENTRATION
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28692
Corresponding AuthorChen, Lianguo
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo,Hu, Chenyan,Guo, Yongyong,et al. TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure[J]. CHEMOSPHERE,2019,217:732-741.
APA Chen, Lianguo,Hu, Chenyan,Guo, Yongyong,Shi, Qipeng,&Zhou, Bingsheng.(2019).TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure.CHEMOSPHERE,217,732-741.
MLA Chen, Lianguo,et al."TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure".CHEMOSPHERE 217(2019):732-741.
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