BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development
Zhou, Wenwen1,2; He, Qiuping2,3; Zhang, Chunxia2,3; He, Xin1; Cui, Zongbin4; Liu, Feng2,3; Li, Wei1,5,6,7,8
2016-10-10
Source PublicationELIFE
ISSN2050-084X
Volume5
AbstractNotch signaling plays a crucial role in controling the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by the Bloc1s2 gene, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysosome-related organelles complex-1 (BLOC-1) and BLOC-1-related complex (BORC). Bloc1s2(-/-) mice were embryonic lethal and exhibited defects in cortical development and hematopoiesis. Loss of BLOS2 resulted in elevated Notch signaling, which consequently increased the proliferation of neural progenitor cells and inhibited neuronal differentiation in cortices. Likewise, ablation of bloc1s2 in zebrafish or mice led to increased hematopoietic stem and progenitor cell production in the aorta-gonad-mesonephros region. BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. Our findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
SubtypeArticle
DOI10.7554/eLife.18108
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(91539204 ; National Natural Science Foundation of China(91539204 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; 31471333 ; 31471333 ; XDA01010110) ; XDA01010110) ; 2011CB943900) ; 2011CB943900) ; 31271570 ; 31271570 ; 31230046 ; 31230046 ; 91332116 ; 91332116 ; 31425016) ; 31425016) ; National Natural Science Foundation of China(91539204 ; National Natural Science Foundation of China(91539204 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; 31471333 ; 31471333 ; XDA01010110) ; XDA01010110) ; 2011CB943900) ; 2011CB943900) ; 31271570 ; 31271570 ; 31230046 ; 31230046 ; 91332116 ; 91332116 ; 31425016) ; 31425016)
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS KeywordLYSOSOME-RELATED ORGANELLES ; DENSE-CORE VESICLES ; HILAR MOSSY CELLS ; INTRACELLULAR TRAFFICKING ; DROSOPHILA-MELANOGASTER ; ENDOSOMAL TRAFFICKING ; ZEBRAFISH EMBRYOS ; CHROMAFFIN CELLS ; DENTATE GYRUS ; ESCRT-II
WOS IDWOS:000387873300001
Funding OrganizationNational Natural Science Foundation of China(91539204 ; National Natural Science Foundation of China(91539204 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; 31471333 ; 31471333 ; XDA01010110) ; XDA01010110) ; 2011CB943900) ; 2011CB943900) ; 31271570 ; 31271570 ; 31230046 ; 31230046 ; 91332116 ; 91332116 ; 31425016) ; 31425016) ; National Natural Science Foundation of China(91539204 ; National Natural Science Foundation of China(91539204 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Chinese Academy of Sciences(KJZD-EW-L08 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; Ministry of Science and Technology of the People's Republic of China(2010CB945300 ; 31471333 ; 31471333 ; XDA01010110) ; XDA01010110) ; 2011CB943900) ; 2011CB943900) ; 31271570 ; 31271570 ; 31230046 ; 31230046 ; 91332116 ; 91332116 ; 31425016) ; 31425016)
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28675
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Affiliation1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Beijing, Peoples R China
5.Capital Med Univ, Beijing Childrens Hosp, Ctr Med Genet, Beijing, Peoples R China
6.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China
7.MOE Key Lab Major Dis Children, Beijing, Peoples R China
8.Beijing Pediat Res Inst, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Wenwen,He, Qiuping,Zhang, Chunxia,et al. BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development[J]. ELIFE,2016,5.
APA Zhou, Wenwen.,He, Qiuping.,Zhang, Chunxia.,He, Xin.,Cui, Zongbin.,...&Li, Wei.(2016).BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.ELIFE,5.
MLA Zhou, Wenwen,et al."BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development".ELIFE 5(2016).
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