IHB OpenIR  > 水环境工程研究中心
The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae
Wang, Xianfeng1,2; Yang, Lihua1; Wang, Qiangwei3; Guo, Yongyong1; Li, Na4; Ma, Mei4; Zhou, Bingsheng1
2016-12-01
Source PublicationJOURNAL OF APPLIED TOXICOLOGY
ISSN0260-437X
Volume36Issue:12Pages:1605-1613
AbstractThe underlying mechanism of polybrominated diphenyl ether (PBDE)-induced neurotoxicity is still a major concern due to its ubiquitous nature and persistence. Here, zebrafish embryos (2h postfertilization, hpf) were exposed to different concentrations of the commercial PBDE mixture DE-71 (0-100 mu gl(-1)) until 120 hpf, and the impact on neural development and serotonergic system was investigated. The in vivo results revealed significantly reduced transcription of genes involved in neurogenesis (fgf8, shha, wnt1), and contents of proteins in neuronal morphogenesis (myelin basic protein, synapsin IIa), suggesting an impairment of neural development in zebrafish embryos. Further results demonstrated a reduction of 5-hydroxytryptamine neuron and a dose-dependent decrease of whole-body serotonin levels, as well as the transcription of genes involved in serotonergic synthesis (tph1, tph2, trhr) and neurotransmission (serta/b, htr1aa/b). In addition, we predicted possible targets of PBDEs by molecular docking, and the results indicated that PBDE congeners showed high binding affinities with fibroblast growth factor 8 other than SHH and HTR1B. Taken together, this study demonstrated that PBDE exposure during embryogenesis could damage neural development and cause impairment of the serotonergic system as secondary effects in the zebrafish larvae. Copyright (c) 2016 John Wiley & Sons, Ltd.
SubtypeArticle
KeywordPbdes Zebrafish Larvae Neural Development Serotonergic System Molecular Docking
DOI10.1002/jat.3322
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(21307153 ; National Natural Science Foundation of China(21307153 ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; 21237005) ; 21237005) ; National Natural Science Foundation of China(21307153 ; National Natural Science Foundation of China(21307153 ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; 21237005) ; 21237005)
Language英语
WOS Research AreaToxicology
WOS SubjectToxicology
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; WNT/BETA-CATENIN PATHWAY ; NEURONAL DIFFERENTIATION ; IN-SILICO ; BRAIN ; EXPOSURE ; DISRUPTION ; EXPRESSION ; DISORDERS
WOS IDWOS:000385782200009
Funding OrganizationNational Natural Science Foundation of China(21307153 ; National Natural Science Foundation of China(21307153 ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; 21237005) ; 21237005) ; National Natural Science Foundation of China(21307153 ; National Natural Science Foundation of China(21307153 ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; 21237005) ; 21237005)
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28667
Collection水环境工程研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
4.Chinese Acad Sci, State Key Lab Environm Aquat Chem, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xianfeng,Yang, Lihua,Wang, Qiangwei,et al. The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae[J]. JOURNAL OF APPLIED TOXICOLOGY,2016,36(12):1605-1613.
APA Wang, Xianfeng.,Yang, Lihua.,Wang, Qiangwei.,Guo, Yongyong.,Li, Na.,...&Zhou, Bingsheng.(2016).The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae.JOURNAL OF APPLIED TOXICOLOGY,36(12),1605-1613.
MLA Wang, Xianfeng,et al."The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae".JOURNAL OF APPLIED TOXICOLOGY 36.12(2016):1605-1613.
Files in This Item:
File Name/Size DocType Version Access License
Wang_et_al-2016-Jour(612KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Xianfeng]'s Articles
[Yang, Lihua]'s Articles
[Wang, Qiangwei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Xianfeng]'s Articles
[Yang, Lihua]'s Articles
[Wang, Qiangwei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Xianfeng]'s Articles
[Yang, Lihua]'s Articles
[Wang, Qiangwei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Wang_et_al-2016-Journal_of_Applied_Toxicology.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.