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A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans
Jiang, Wei1,2,3,4; Wei, Yuehua1,4; Long, Yong1,4,5; Owen, Arthur6; Wang, Bingying1,4; Wu, Xuebing7; Luo, Shuo7; Dang, Yongjun2,3; Ma, Dengke K.1,4
Corresponding AuthorMa, Dengke K.(Dengke.Ma@ucsf.edu)
2018-04-17
Source PublicationELIFE
ISSN2050-084X
Volume7Pages:19
AbstractHow multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60, zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolonged zip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, of C. elegans. zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions.
DOI10.7554/eLife.35037
Funding OrganizationChina Postdoctoral Science Foundation ; National Institute on Aging ; National Institute of General Medical Sciences ; Pew Charitable Trusts ; American Diabetes Association ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute ; China Postdoctoral Science Foundation ; National Institute on Aging ; National Institute of General Medical Sciences ; Pew Charitable Trusts ; American Diabetes Association ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute
Indexed BySCI ; SCI
Language英语
Funding ProjectChina Postdoctoral Science Foundation ; National Institute on Aging[R01AG032435] ; National Institute of General Medical Sciences[R01GM117461] ; Pew Charitable Trusts ; American Diabetes Association[1-16-IBS-197] ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute[R00HL116654]
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000458481900001
WOS KeywordHEAT-SHOCK RESPONSE ; OXIDATIVE STRESS ; MESSENGER-RNA ; CELL-DEATH ; MECHANISMS ; TRANSCRIPTION ; YEAST ; HYPOTHERMIA ; ADAPTATION ; APOPTOSIS
PublisherELIFE SCIENCES PUBLICATIONS LTD
Funding OrganizationChina Postdoctoral Science Foundation ; National Institute on Aging ; National Institute of General Medical Sciences ; Pew Charitable Trusts ; American Diabetes Association ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute ; China Postdoctoral Science Foundation ; National Institute on Aging ; National Institute of General Medical Sciences ; Pew Charitable Trusts ; American Diabetes Association ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28609
Corresponding AuthorMa, Dengke K.
Affiliation1.Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA
2.Fudan Univ, Key Lab Metab & Mol Med, Minist Educ, Shanghai, Peoples R China
3.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai, Peoples R China
4.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94103 USA
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
6.Univ Calif Berkeley, Dept Mol Cell Biol, Berkeley, CA 94720 USA
7.MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA
Recommended Citation
GB/T 7714
Jiang, Wei,Wei, Yuehua,Long, Yong,et al. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans[J]. ELIFE,2018,7:19.
APA Jiang, Wei.,Wei, Yuehua.,Long, Yong.,Owen, Arthur.,Wang, Bingying.,...&Ma, Dengke K..(2018).A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans.ELIFE,7,19.
MLA Jiang, Wei,et al."A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans".ELIFE 7(2018):19.
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