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题名: Chemical proteomic analysis of the potential toxicological mechanisms of microcystin-RR in zebrafish (Danio rerio) liver
作者: Tuo, Xun1, 2, 3; Chen, Jun1; Zhao, Sujuan1, 3; Xie, Ping1
关键词: microcystin-RR ; chemical proteomics ; toxicological mechanisms ; zebrafish ; liver
刊名: ENVIRONMENTAL TOXICOLOGY
发表日期: 2016-10-01
DOI: 10.1002/tox.22128
卷: 31, 期:10, 页:1206-1216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Environmental Sciences ; Toxicology ; Water Resources
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology ; Water Resources
英文摘要: Microcystins (MCs) are common toxins produced by freshwater cyanobacteria, and they represent a potential health risk to aquatic organisms and animals, including humans. Specific inhibition of protein phosphatases 1 and 2A is considered the typical mechanism of MCs toxicity, but the exact mechanism has not been fully elucidated. To further our understanding of the toxicological mechanisms induced by MCs, this study is the first to use a chemical proteomic approach to screen proteins that exhibit special interactions with MC-arginine-arginine (MC-RR) from zebrafish (Danio rerio) liver. Seventeen proteins were identified via affinity blocking test. Integration of the results of previous studies and this study revealed that these proteins play a crucial role in various toxic phenomena of liver induced by MCs, such as the disruption of cytoskeleton assembly, oxidative stress, and metabolic disorder. Moreover, in addition to inhibition of protein phosphate activity, the overall toxicity of MCs was simultaneously modulated by the distribution of MCs in cells and their interactions with other target proteins. These results provide new insight into the mechanisms of hepatotoxicity induced by MCs. (c) 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1206-1216, 2016.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; AFFINITY-CHROMATOGRAPHY ; RAT HEPATOCYTES ; INTERMEDIATE-FILAMENTS ; PROTEIN PHOSPHATASES ; PROTEOLYTIC-ENZYMES ; CELLULAR-RESPONSES ; SERINE PROTEASES ; MOUSE-LIVER ; FISH LIVER
语种: 英语
项目资助者: National Natural Science Foundation of China(31322013 ; 31070457)
WOS记录号: WOS:000383611900005
ISSN号: 1520-4081
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/28567
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7, Wuhan 430072, Peoples R China
2.Nanchang Univ, Basic Chem Expt Ctr, Nanchang 330031, Jiangxi, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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