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Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma
Zhang,Yong1; Hu,Xiaoyan1; Hu,Yue1; Teng,Kai2; Zhang,Kai1; Zheng,Yamei3; Hong,Xiaohua1; Yu,Kunwu4; Wang,Yan5; Liu,Li1
Corresponding AuthorLiu,Li(liulist2013@163.com)
2015-02-05
Source PublicationJournal of Experimental & Clinical Cancer Research
ISSN1756-9966
Volume34Issue:1
AbstractAbstractBackgroundAgonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agonistic CD40 antibody-mediated inflammatory responses, a novel subset of E-cadherin + dendritic cells (DCs) has been identified, and little is known about the role of these DCs in tumour immunity. This study investigated the effect of anti-CD40-mediated inflammatory E-cadherin + DCs in murine Lewis lung carcinoma (LLC).MethodsThe phenotype and characteristics of anti-CD40-mediated inflammatory E-cadherin + DCs isolated from the anti-CD40 model were assessed in vitro. The antitumour activity of E-cadherin + DCs were evaluated in vivo by promoting the differentiation of effector CD4+ T cells, CEA-specific CD8+ T cells and CD103+ CD8+ T cells and assessing their resistance to tumour challenge, including variations in tumour volume and survival curves.ResultsHere, we demonstrated that anti-CD40-mediated E-cadherin + inflammatory DCs accumulate in the lungs of Rag1 KO mice and were able to stimulate na?ve CD4+ T cells to induce Th1 and Th17 cell differentiation and polarisation and to inhibit regulatory T cell and Th2 responses. Importantly, with the adoptive transfer of E-cadherin + DCs into the Lewis lung cancer model, the inflammatory DCs increased the Th1 and Th17 cell responses and reduced the Treg cell and Th2 responses. Interestingly, following the injection of inflammatory E-cadherin + DCs, the CD103+ CD8+ T cell and CEA-specific CD8+ T cell responses increased and exhibited potent antitumour immunity.ConclusionsThese findings indicate that anti-CD40-induced E-cadherin + DCs enhance T cell responses and antitumour activity in non-small cell lung cancer (NSCLC)-bearing mice and may be used to enhance the efficacy of DC-based peptide vaccines against NSCLC.
KeywordE-cadherin Dendritic cell T cell Lung cancer Activity
DOI10.1186/s13046-015-0126-9
Language英语
WOS IDBMC:10.1186/s13046-015-0126-9
PublisherBioMed Central
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28550
Collection分析测试中心_期刊论文
Corresponding AuthorLiu,Li
Affiliation1.Tongji Medical College of Huazhong University of Science and Technology; Cancer Center, Union Hospital
2.Hainan Cancer Hospital
3.Central Hospital of Wuhan; Department of oncology
4.Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital
5.Institute of Hydro Biololgy, Chinese Academy of Sciences, Analysis and Testing center
Recommended Citation
GB/T 7714
Zhang,Yong,Hu,Xiaoyan,Hu,Yue,et al. Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma[J]. Journal of Experimental & Clinical Cancer Research,2015,34(1).
APA Zhang,Yong.,Hu,Xiaoyan.,Hu,Yue.,Teng,Kai.,Zhang,Kai.,...&Liu,Li.(2015).Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.Journal of Experimental & Clinical Cancer Research,34(1).
MLA Zhang,Yong,et al."Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma".Journal of Experimental & Clinical Cancer Research 34.1(2015).
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