IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents
Du,Kang1,2; Yang,Liandong1,2; He,Shunping1
Corresponding AuthorHe,Shunping(clad@ihb.ac.cn)
2015-12-18
Source PublicationBMC Evolutionary Biology
ISSN1471-2148
Volume15Issue:1
AbstractAbstractBackgroundGenome-wide signatures of convergent evolution are widely expected but rarely revealed in animals. Subterranean rodent genome and transcriptome data produced by next-generation sequencing facilitate the use of phylogenetic methods to infer non-synonymous and synonymous substitution rates within coding regions, which can reveal changes at the molecular level that are correlated with the dramatic shift from a terrestrial to subterranean habitat.ResultsOur study used previously sequenced genome or transcriptome data of two subterranean rodents, the blind mole rat and naked mole rat, and their terrestrial relatives, the mouse and guinea pig, to investigate the genetic basis of rodent subterranean adaptation. An analysis of 4996 orthologous genes revealed that the substitution pace of coding sequences was significantly slower in the blind mole rat than in the mouse, and slower in the naked mole rat than in the guinea pig. The dN/dS ratio was significantly higher in the blind mole rat than in the mouse and in the naked mole rat than in the guinea pig. These patterns are most likely related to the longer generation time and lower effective population size of subterranean rodents caused by subterranean ecological constraints. We also identified some genes and gene ontology (GO) categories that might be candidates for adaptation to subterranean life.ConclusionsOur study reveals a case of subterranean convergent evolution in rodents that is correlated with change in the pace and mode of molecular evolution observed at the genome scale. We believe that this genomic signature could have also evolved in other cases of subterranean convergence. Additionally, the genes that displayed the most radical changes in their patterns of evolution and their associated GO categories provide a strong basis for further comparative and functional studies, and potentially reveal molecular signatures of adaptation to subterranean life.
KeywordSubterranean rodents Convergent evolution dN/dS Substitution rate Positive selection
DOI10.1186/s12862-015-0564-1
Language英语
WOS IDBMC:10.1186/s12862-015-0564-1
PublisherBioMed Central
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28521
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorHe,Shunping
Affiliation1.Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Du,Kang,Yang,Liandong,He,Shunping. Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents[J]. BMC Evolutionary Biology,2015,15(1).
APA Du,Kang,Yang,Liandong,&He,Shunping.(2015).Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents.BMC Evolutionary Biology,15(1).
MLA Du,Kang,et al."Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents".BMC Evolutionary Biology 15.1(2015).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Du,Kang]'s Articles
[Yang,Liandong]'s Articles
[He,Shunping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Du,Kang]'s Articles
[Yang,Liandong]'s Articles
[He,Shunping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Du,Kang]'s Articles
[Yang,Liandong]'s Articles
[He,Shunping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.