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The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae
Zhu, Biran1; He, Wei2; Hu, Shengchao3; Kong, Ren4; Yang, Lihua3
Corresponding AuthorZhu, Biran(zhubir@hotmail.com) ; Yang, Lihua(lhyang@ihb.ac.cn)
2019-06-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume225Pages:705-712
AbstractNanoparticle such as silicon dioxide nanoparticles (nano-SiO2) are extensively produced and applied in society. Hence there is an increasing concern about their exposure and toxicity to human and wildlife. To understand the effects of sizes of NPs on their bioavailability and toxicity, zebrafish (Danio rerio) embryos (2 h post-fertilization, hpf) were exposed to 25, 50 and 100 mg/L of 15 or 30 nm nano-SiO2 for 5 days respectively. The results showed that SiO2 could be readily uptaken by zebrafish, and the accumulation of SiO2 was significantly higher in 15 nm treatments groups compared to 30 nm nano-SiO2 treated groups. Furthermore, exposure to 15 nm nano-SiO2 at the concentration of 100 mg/L resulted in more significant changes in reactive oxygen species (ROS) levels, perturbation of lipid peroxidative and antioxidant system than the same concentration of 30 nm nano-SiO2, indicating small sized nano-SiO2 evoked severer oxidative stress in zebrafish larvae. In addition, the more significant up-regulation of transcription of genes related to oxidative stress (e.g., nrf2 and sod1) in 15 nm nano-SiO2 at the 100 mg/L treatments groups provided more evidence for this speculation. Given the above, 15 nm nano-SiO2 were more likely to enter and accumulate in zebrafish larvae, thus causing more serious oxidative stress in vivo. These results may provide additional information on the fate and toxicities of different sizes of NPs. (C) 2019 Elsevier Ltd. All rights reserved.
KeywordSilicon dioxide nanoparticles (nano-SiO2) Zebrafish larvae Oxidative stress Bioaccumulation
DOI10.1016/j.chemosphere.2019.03.091
Funding OrganizationHealth Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project
Indexed BySCI ; SCI
Language英语
Funding ProjectHealth Commission of Hubei Province scientific research project[WJ2019X006]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000467668500076
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; DECABROMODIPHENYL ETHER ; SILICA NANOPARTICLES ; APOPTOSIS ; TOXICITY ; IMPACT ; METABOLISM ; PATHWAYS ; BDE-209 ; NRF2
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Funding OrganizationHealth Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project ; Health Commission of Hubei Province scientific research project
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28493
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhu, Biran; Yang, Lihua
Affiliation1.Hubei Univ Chinese Med, Sch Basic Med Sci, Wuhan 430065, Hubei, Peoples R China
2.Hubei Univ, Sch Comp Sci & Informat Engn, Wuhan 430062, Hubei, Peoples R China
3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Biran,He, Wei,Hu, Shengchao,et al. The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae[J]. CHEMOSPHERE,2019,225:705-712.
APA Zhu, Biran,He, Wei,Hu, Shengchao,Kong, Ren,&Yang, Lihua.(2019).The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae.CHEMOSPHERE,225,705-712.
MLA Zhu, Biran,et al."The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae".CHEMOSPHERE 225(2019):705-712.
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