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Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection
Zhang, Peiyu1,2; Fu, Lele1,2; Liu, Haokun1; Huda, Noor-Ul1,2; Zhu, Xiaoming1; Han, Dong1,3; Jin, Junyan1; Yang, Yunxia1; Kim, Yang-Su4; Xie, Shouqi1
Corresponding AuthorLiu, Haokun(liuhaokun@ihb.ac.cn)
2019-03-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume86Pages:913-921
AbstractThe present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS III) (initial body weight: 7.48 g). Six diets were formulated containing exogenous 5'-IMP at three gradient levels (0, 0.1% and 0.2%) in the high dietary fishmeal group (15% fishmeal: Dl, D2, D3) and in the high dietary soybean meal group (33% soybean meal: D4, D5, D6). Each diet was randomly allotted to triplicate tanks in a recirculating system. After the feeding trial, fish were exposed to Aeromonas hydrophila challenge. Hematological and immunological responses were analyzed before and after challenge. The results indicated that feeding rate in all 5'-IMP supplemented treatments (D2, D3, D5 and D6) and daily growth coefficient in D5 and D6 were reduced compared with those of respective control treatments (Dl and D4) without 5'-IMP addition (P < 0.05). The cumulative survival rates were numerically improved by dietary 5'-IMP supplementation (P > 0.05). Compared with the respective control treatment, in the high fishmeal group, plasma SOD and MPO were significantly elevated in D3 at the end of feeding trial (P < 0.05), plasma SOD and lysozyme were significantly increased in D3 after bacterial challenge (P < 0.05); in high soybean meal group, plasma lysozyme activity was significantly elevated in D5 post bacterial challenge (P < 0.05). Most of the expression of immune related genes (intelectin, major histocompatibility complex class II beta (MHC II beta), Complement 3 (C3), Complement component C7-1 (ccC7), lysozyme C, Interleukin 1 beta (IL-1 beta), Tumor necrosis factor alpha 1 (TNF-alpha 1), Transforming growth factor-beta (TGE-beta) and Interleukin 8 (IL-8)) in spleen, kidney and liver of the fish were significantly affected by supplementation of 5'-IMP at the end of feeding trial and post bacterial challenge. Additionally, adding 5'-IMP in high soybean meal diets exerted further effects of promoting immunity than counterparts in high fishmeal diets. Considering enhanced disease resistance, the immunopotentiation of 5'-IMP was manifested when the addition level was 0.1% in high soybean meal diets and 0.2% in high fishmeal diets.
Keyword5'-IMP Carassius auratus gibelio Immunity Disease resistance Aeromonas hydrophila
DOI10.1016/j.fsi.2018.12.016
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31602174] ; National Natural Science Foundation of China[31672670] ; Natural Science Foundation of Hubei[2016CFB282] ; Key Project of Hubei Provincial Science and Technology Department[2015BBA226] ; Youth Talent Support Program of IHB[Y75E041201] ; China Agriculture Research System[CARS-45-09] ; Major Science and Technology Program for Water Pollution Control and Treatment[2017ZX07203001] ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ05] ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ06]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000459528400100
WOS KeywordENDOTHELIAL-CELLS ; GUT MORPHOLOGY ; RAINBOW-TROUT ; NITRIC-OXIDE ; JUVENILE AMBERJACK ; DISEASE RESISTANCE ; STRESS RESISTANCE ; INNATE IMMUNITY ; NILE TILAPIA ; NUCLEOTIDES
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28066
Collection淡水生态学研究中心
Corresponding AuthorLiu, Haokun
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430070, Hubei, Peoples R China
4.CJ Cheiljedang Ctr, CJ Cheiljedang BIO Tech Mkt Team, Seoul 04560, South Korea
Recommended Citation
GB/T 7714
Zhang, Peiyu,Fu, Lele,Liu, Haokun,et al. Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:913-921.
APA Zhang, Peiyu.,Fu, Lele.,Liu, Haokun.,Huda, Noor-Ul.,Zhu, Xiaoming.,...&Xie, Shouqi.(2019).Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection.FISH & SHELLFISH IMMUNOLOGY,86,913-921.
MLA Zhang, Peiyu,et al."Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection".FISH & SHELLFISH IMMUNOLOGY 86(2019):913-921.
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