IHB OpenIR  > 水生生物分子与细胞生物学研究中心
Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)
Wang, Kai-Zhuo1; Feng, Lin1,2,3; Jiang, Wei-Dan1,2,3; Wu, Pei1,2,3; Liu, Yang1,2,3; Jiang, Jun1; Kuang, Sheng-Yao4; Tang, Ling4; Zhang, Yong-An5; Zhou, Xiao-Qiu1,2,3
Corresponding AuthorZhou, Xiao-Qiu(xqzhouqq@tom.com)
2019-03-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume86Pages:814-831
AbstractThe present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and beta-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interferon gamma 2 (IFN-gamma 2), interleukin 1 beta (IL-1 beta), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-kappa B) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-beta 1, TGF-beta 2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-kappa Bp52, IKK alpha and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.
KeywordGossypol Grass carp (Ctenopharyngodon idella) Intestinal immunity NF-kappa B signalling TOR signalling
DOI10.1016/j.fsi.2018.12.014
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Basic Research Program of China (973 Program)[2014CB138600] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Earmarked Fund for China Agriculture Research System[CARS-45] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007] ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000459528400089
WOS KeywordNF-KAPPA-B ; TIGHT JUNCTION PROTEIN ; GROWTH-PERFORMANCE ; STRUCTURAL INTEGRITY ; HEAD KIDNEY ; AEROMONAS-HYDROPHILA ; SIGNALING PATHWAYS ; ADAPTIVE IMMUNITY ; ATLANTIC SALMON ; OXIDATIVE STRESS
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28039
Collection水生生物分子与细胞生物学研究中心
Corresponding AuthorZhou, Xiao-Qiu
Affiliation1.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China
3.Sichuan Agr Univ, China Minist Educ, Key Lab Anim Dis Resistance Nutr, Chengdu 611130, Sichuan, Peoples R China
4.Sichuan Acad Anim Sci, Inst Anim Nutr, Chengdu 610066, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kai-Zhuo,Feng, Lin,Jiang, Wei-Dan,et al. Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:814-831.
APA Wang, Kai-Zhuo.,Feng, Lin.,Jiang, Wei-Dan.,Wu, Pei.,Liu, Yang.,...&Zhou, Xiao-Qiu.(2019).Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).FISH & SHELLFISH IMMUNOLOGY,86,814-831.
MLA Wang, Kai-Zhuo,et al."Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)".FISH & SHELLFISH IMMUNOLOGY 86(2019):814-831.
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