IHB OpenIR  > 水环境工程研究中心
High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae
Chen, Lianguo1,2; Zhu, Biran1; Guo, Yongyong1; Xu, Tao3; Lee, Jae-Seong4; Qian, Pei-Yuan2; Zhou, Bingsheng1
2016-07-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume214Pages:324-333
AbstractPBDEs and heavy metals are two major contaminants at e-waste disposal sites, but their combined effects remain largely unexplored. In the present study, the transcriptomic profiles of zebrafish larvae were examined after acute exposure of embryos to 200 mu g/L BDE-209, 20 mu g/L lead (Pb) or their mixture (Mix). Stimulation of steroidogenic pathway and vitellogenesis in the BDE-209 and Mix treatments indicated the estrogenic activities of BDE-209, while Pb antagonized those estrogenic effects in the Mix treatment. Increased heart rates were observed in zebrafish exposed to the Pb and Mix treatments. The cardiac dysfunction probably resulted from the promotion of angiogenesis, increased adrenergic drive and induction of the formation of blood clot. Furthermore, the Pb and Mix treatments activated neuroendocrine regulation of the pituitary in a positive feedback loop, via the thyrotropin-releasing hormone receptor, thus increasing thyroid hormone production self-adaptively. Overall, the interaction between BDE-209 and Pb led to synergistic and antagonistic effects on gene transcriptions, with concerted contribution from their individual toxicological properties. (C) 2016 Published by Elsevier Ltd.
SubtypeArticle
KeywordBde-209 Pb Zebrafish Embryos Developmental Co-exposure Transcriptome
DOI10.1016/j.envpol.2016.04.040
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(21237005) ; National Natural Science Foundation of China(21237005) ; Chinese Academy of Sciences(XDB14040103) ; Chinese Academy of Sciences(XDB14040103) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Natural Science Foundation of China(21237005) ; National Natural Science Foundation of China(21237005) ; Chinese Academy of Sciences(XDB14040103) ; Chinese Academy of Sciences(XDB14040103) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047)
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; MEDAKA ORYZIAS-MELASTIGMA ; HEALTH CONSEQUENCES ; ELECTRONIC-WASTE ; HEAVY-METALS ; SOUTH CHINA ; EXPOSURE ; FISH ; RECEPTOR ; PBDES
WOS IDWOS:000378448600037
Funding OrganizationNational Natural Science Foundation of China(21237005) ; National Natural Science Foundation of China(21237005) ; Chinese Academy of Sciences(XDB14040103) ; Chinese Academy of Sciences(XDB14040103) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Natural Science Foundation of China(21237005) ; National Natural Science Foundation of China(21237005) ; Chinese Academy of Sciences(XDB14040103) ; Chinese Academy of Sciences(XDB14040103) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047)
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/28016
Collection水环境工程研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
3.Huazhong Univ Sci & Technol, Puai Hosp, Wuhan 430033, Peoples R China
4.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea
Recommended Citation
GB/T 7714
Chen, Lianguo,Zhu, Biran,Guo, Yongyong,et al. High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae[J]. ENVIRONMENTAL POLLUTION,2016,214:324-333.
APA Chen, Lianguo.,Zhu, Biran.,Guo, Yongyong.,Xu, Tao.,Lee, Jae-Seong.,...&Zhou, Bingsheng.(2016).High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae.ENVIRONMENTAL POLLUTION,214,324-333.
MLA Chen, Lianguo,et al."High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae".ENVIRONMENTAL POLLUTION 214(2016):324-333.
Files in This Item:
File Name/Size DocType Version Access License
1-s2.0-S026974911630(1807KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Lianguo]'s Articles
[Zhu, Biran]'s Articles
[Guo, Yongyong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Lianguo]'s Articles
[Zhu, Biran]'s Articles
[Guo, Yongyong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Lianguo]'s Articles
[Zhu, Biran]'s Articles
[Guo, Yongyong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0269749116303074-main.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.