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A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure
Zhao, Sujuan; Xie, Ping; Chen, Jun; Liu, Luyi; Fan, Huihui
2016-05-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume212Pages:197-207
AbstractThere is mounting evidence indicating that microcystins (MCs) are heptapeptide toxins. Recent studies have also shown that MCLR can transfer from mother to offspring, but it is unclear whether maternal MCLR can influence the liver of offspring or not. In this study, pregnant SD rats were injected intraperitoneally with a saline solution (control) or 10 mu g/kg MCLR per day from gestational day 8 (GD8) to postnatal day 15 (PD15) for a total of 4 weeks. 2-DE and MALDI-TOF-TOF mass spectrometry were used to screen for MCLR target proteins in the livers of rat pups. Our results demonstrated that MCLR could accumulate in the livers of neonatal rats. Proteomics studies also showed that MCLR significantly influenced many proteins, including those involved in the cytoskeleton, metabolism and particularly oxidative stress. In addition, MCLR induced cellular structural damage and resulted in the production of intracellular reactive oxygen species (ROS) and lipid peroxidation. Moreover, protein phosphatase (PP) activity was inhibited and some serum biochemistry parameters were altered. These results suggest an early molecular mechanism behind the hepatotoxicity induced by maternal MC exposure and highlight the importance of monitoring MC concentrations in new-born mammals. (C) 2016 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordMclr Rat Pups Proteomics Liver Oxidative Damage
DOI10.1016/j.envpol.2015.12.055
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457)
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS KeywordINDUCED DNA-DAMAGE ; IN-VIVO ; ALDEHYDE DEHYDROGENASE ; CELLS ; CYANOBACTERIA ; GLUTATHIONE ; METABOLISM ; TOXICITY ; HEALTH ; TOXIN
WOS IDWOS:000376800000024
Funding OrganizationNational Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457) ; National Natural Science Foundation of China(31070457)
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27980
Collection淡水生态学研究中心
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Sujuan,Xie, Ping,Chen, Jun,et al. A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure[J]. ENVIRONMENTAL POLLUTION,2016,212:197-207.
APA Zhao, Sujuan,Xie, Ping,Chen, Jun,Liu, Luyi,&Fan, Huihui.(2016).A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure.ENVIRONMENTAL POLLUTION,212,197-207.
MLA Zhao, Sujuan,et al."A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure".ENVIRONMENTAL POLLUTION 212(2016):197-207.
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