| Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders | |
| Lu, Suxiang1,2,3; Yang, Liandong1; Jiang, Haifeng1,2; Chen, Juan1,2; Yu, Guangqing1,2; Chen, Zhiguo3; Xia, Xichao3; He, Shunping1 | |
| Corresponding Author | He, Shunping(clad@ihb.ac.cn) |
| 2019-03-30 | |
| Source Publication | GENE
 |
| ISSN | 0378-1119 |
| Volume | 690Pages:68-74 |
| Abstract | Bichirs are a sister group to sarcopterygian and tetrapods that can fully regenerate their endochondral-skeleton-fins. Histological and transcriptomic comparison approaches have been used to investigate the morphology and genetic basis of bichir lobe-fin regeneration, with strong down-regulation of muscle-related genes and up-regulation of ECM-related genes and developmental genes being observed. Bichir limb regeneration involves similar cellular processes to those employed by lungfish and salamander, with MARCKS-like protein (MLP) that is known to be a putative regeneration-initiating molecule in salamander, also up-regulated in the early stages of bichir lobe-fin regeneration. These gene expression results suggest that limb regeneration pathways in these amphibians have a common ancestral inheritance, consistent with evolution from endochondral-skeleton-fin structures to endochondral-skeleton-limb structures of vertebrates. |
| Keyword | Regeneration Polypterus Evolution Transcriptome Lobe-fin MARCKS-like protein |
| DOI | 10.1016/j.gene.2018.12.031 |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB06010105] |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000458707600008 |
| WOS Keyword | MARCKS-LIKE PROTEIN ; EXPRESSION ANALYSIS ; BLASTEMA FORMATION ; PROTEOMIC ANALYSIS ; TETRAPOD LIMB ; AXOLOTL ; EVOLUTION ; IDENTIFICATION ; POLYPTERUS ; LESSONS |
| Publisher | ELSEVIER SCIENCE BV |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/27968 |
| Collection | 水生生物多样性与资源保护研究中心 |
| Corresponding Author | He, Shunping |
| Affiliation | 1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Pingdingshan Univ, Med Coll, Pingdingshan 467000, Henan, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Suxiang,Yang, Liandong,Jiang, Haifeng,et al. Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders[J]. GENE,2019,690:68-74. |
| APA | Lu, Suxiang.,Yang, Liandong.,Jiang, Haifeng.,Chen, Juan.,Yu, Guangqing.,...&He, Shunping.(2019).Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders.GENE,690,68-74. |
| MLA | Lu, Suxiang,et al."Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders".GENE 690(2019):68-74. |
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