IHB OpenIR  > 水生生物多样性与资源保护研究中心
Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders
Lu, Suxiang1,2,3; Yang, Liandong1; Jiang, Haifeng1,2; Chen, Juan1,2; Yu, Guangqing1,2; Chen, Zhiguo3; Xia, Xichao3; He, Shunping1
Corresponding AuthorHe, Shunping(clad@ihb.ac.cn)
2019-03-30
Source PublicationGENE
ISSN0378-1119
Volume690Pages:68-74
AbstractBichirs are a sister group to sarcopterygian and tetrapods that can fully regenerate their endochondral-skeleton-fins. Histological and transcriptomic comparison approaches have been used to investigate the morphology and genetic basis of bichir lobe-fin regeneration, with strong down-regulation of muscle-related genes and up-regulation of ECM-related genes and developmental genes being observed. Bichir limb regeneration involves similar cellular processes to those employed by lungfish and salamander, with MARCKS-like protein (MLP) that is known to be a putative regeneration-initiating molecule in salamander, also up-regulated in the early stages of bichir lobe-fin regeneration. These gene expression results suggest that limb regeneration pathways in these amphibians have a common ancestral inheritance, consistent with evolution from endochondral-skeleton-fin structures to endochondral-skeleton-limb structures of vertebrates.
KeywordRegeneration Polypterus Evolution Transcriptome Lobe-fin MARCKS-like protein
DOI10.1016/j.gene.2018.12.031
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences
Indexed BySCI ; SCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDB06010105]
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000458707600008
WOS KeywordMARCKS-LIKE PROTEIN ; EXPRESSION ANALYSIS ; BLASTEMA FORMATION ; PROTEOMIC ANALYSIS ; TETRAPOD LIMB ; AXOLOTL ; EVOLUTION ; IDENTIFICATION ; POLYPTERUS ; LESSONS
PublisherELSEVIER SCIENCE BV
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27968
Collection水生生物多样性与资源保护研究中心
Corresponding AuthorHe, Shunping
Affiliation1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Pingdingshan Univ, Med Coll, Pingdingshan 467000, Henan, Peoples R China
Recommended Citation
GB/T 7714
Lu, Suxiang,Yang, Liandong,Jiang, Haifeng,et al. Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders[J]. GENE,2019,690:68-74.
APA Lu, Suxiang.,Yang, Liandong.,Jiang, Haifeng.,Chen, Juan.,Yu, Guangqing.,...&He, Shunping.(2019).Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders.GENE,690,68-74.
MLA Lu, Suxiang,et al."Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders".GENE 690(2019):68-74.
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