IHB OpenIR  > 淡水生态学研究中心
A review of neurotoxicity of microcystins
Hu, Yufei1,2; Chen, Jun1; Fan, Huihui3; Xie, Ping1; He, Jun1
2016-04-01
Source PublicationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN0944-1344
Volume23Issue:8Pages:7211-7219
AbstractCyanobacterial blooms-produced microcystins are secondary metabolites which can accumulate in the food chain and contaminate water, thus posing a potential threat to the health of aquatic animals and even humans. Microcystin toxicity affects not only the liver but also the other organs, i.e., the brain. The serious neurotoxicity effects caused by microcystins then lead to various symptoms. This review focuses on the neurotoxicity of microcystins. Microcystins can cross blood-brain barrier with the transport of Oatps/OATPs, causing neurostructural, functional, and behavioral changes. In this review, potential uptake mechanisms and neurotoxicity mechanisms are summarized, including neurotransmissions, neurochannels, signal transduction, oxidative stress, and cytoskeleton disruption. However, further researches are needed for detailed studies on signaling pathways and the downstream pathways of neurotoxicity of microcystins.
SubtypeReview
KeywordMicrocystins Brain Neurotoxicity Oatps/oatps Toxic Effects Mechanisms
DOI10.1007/s11356-016-6073-y
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundations of China(31322013) ; National Natural Science Foundations of China(31322013) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; National Natural Science Foundations of China(31322013) ; National Natural Science Foundations of China(31322013) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02)
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS KeywordANION-TRANSPORTING POLYPEPTIDES ; NEMATODE CAENORHABDITIS-ELEGANS ; FRESH-WATER BIVALVES ; DANIO-RERIO ; PARKINSONS-DISEASE ; PP2A INHIBITION ; TARGET ESTERASE ; PROTEIN-KINASE ; LR EXPOSURE ; BRAIN
WOS IDWOS:000374994600018
Funding OrganizationNational Natural Science Foundations of China(31322013) ; National Natural Science Foundations of China(31322013) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; National Natural Science Foundations of China(31322013) ; National Natural Science Foundations of China(31322013) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FBZ02)
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27960
Collection淡水生态学研究中心
Affiliation1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Wenzhou Med Univ, Dept Prevent Med, Wenzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Hu, Yufei,Chen, Jun,Fan, Huihui,et al. A review of neurotoxicity of microcystins[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2016,23(8):7211-7219.
APA Hu, Yufei,Chen, Jun,Fan, Huihui,Xie, Ping,&He, Jun.(2016).A review of neurotoxicity of microcystins.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,23(8),7211-7219.
MLA Hu, Yufei,et al."A review of neurotoxicity of microcystins".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 23.8(2016):7211-7219.
Files in This Item:
File Name/Size DocType Version Access License
art%3A10.1007%2Fs113(459KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Yufei]'s Articles
[Chen, Jun]'s Articles
[Fan, Huihui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Yufei]'s Articles
[Chen, Jun]'s Articles
[Fan, Huihui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Yufei]'s Articles
[Chen, Jun]'s Articles
[Fan, Huihui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: art%3A10.1007%2Fs11356-016-6073-y.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.