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题名: Stimulatory effect of the secretogranin-11 derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)
作者: Mikwar, M.1; Navarro-Martin, L.; Xing, L.1; Volkoff, H.2; Hu, W.3; Trudeau, V. L.1
关键词: Feeding ; Locomotion ; Secretogranin-II ; Secretoneurin ; Fish
刊名: PEPTIDES
发表日期: 2016-04-01
DOI: 10.1016/j.peptides.2016.01.007
卷: 78, 页:42-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
英文摘要: Secretoneurin (SN) is a conserved peptide derived by proteolytic processing from the middle domain of the similar to 600 amino acid precursor secretogranin-II (SgII). Secretoneurin is widely distributed in secretory granules of endocrine cells and neurons and has important roles in reproduction as it stimulates luteinizing hormone release from the pituitary. A potential new role of SN in goldfish feeding is the subject of this study. Firstly, we established that acute (26h; p < 0.0001) and short-term (72 h; p = 0.016) fasting increased SgIIa precursor mRNA levels 1.25-fold in the telencephalon, implicating SN in the control of feeding. Secondly, we determined that intracerebroventricular injections of the type A SN (SNa; 0.2 and 1 ng/g BW) increased food intake and locomotor behavior by 60 min. Fish injected with the lower and higher doses of SNa (0.2 and 1 ng/g) respectively exhibited significant 1.77- and 2.58-fold higher food intake (p < 0.0001) than the saline-injected control fish. Locomotor behavior was increased by 1.35- and 2.26-fold for 0.2 ng/g SNa (p = 0.0001) and 1 ng/g SNa (p < 0.0001), respectively. Injection of 1 ng/g SNa increased mRNA levels of hypothalamic neuropeptide Y 1.36-fold (p = 0.038) and decreased hypothalamic cocaine-and amphetamine-regulated transcript by 33% (p = 0.01) at 2 h and 5 h post-injection, respectively. These data suggest interactions of SNa with stimulatory and inhibitory pathways of food intake control in fish. (C) 2016 Elsevier Inc. All rights reserved.
关键词[WOS]: DIFFUSE NEUROENDOCRINE SYSTEM ; NEUROPEPTIDE-Y ; IMMUNOHISTOCHEMICAL LOCALIZATION ; LUTEINIZING-HORMONE ; FEEDING-BEHAVIOR ; OREXIN-A ; PITUITARY ; BRAIN ; EXPRESSION ; IMMUNOREACTIVITY
语种: 英语
项目资助者: NSERC-Discovery, uOttawa International Research Acceleration Programs ; Ministry of Higher Education of Saudi Arabia
WOS记录号: WOS:000372718700006
ISSN号: 0196-9781
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27935
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada
2.Mem Univ Newfoundland, Dept Biol, St John, NF, Canada
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
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