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Stimulatory effect of the secretogranin-11 derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)
Mikwar, M.1; Navarro-Martin, L.; Xing, L.1; Volkoff, H.2; Hu, W.3; Trudeau, V. L.1
2016-04-01
Source PublicationPEPTIDES
ISSN0196-9781
Volume78Pages:42-50
AbstractSecretoneurin (SN) is a conserved peptide derived by proteolytic processing from the middle domain of the similar to 600 amino acid precursor secretogranin-II (SgII). Secretoneurin is widely distributed in secretory granules of endocrine cells and neurons and has important roles in reproduction as it stimulates luteinizing hormone release from the pituitary. A potential new role of SN in goldfish feeding is the subject of this study. Firstly, we established that acute (26h; p < 0.0001) and short-term (72 h; p = 0.016) fasting increased SgIIa precursor mRNA levels 1.25-fold in the telencephalon, implicating SN in the control of feeding. Secondly, we determined that intracerebroventricular injections of the type A SN (SNa; 0.2 and 1 ng/g BW) increased food intake and locomotor behavior by 60 min. Fish injected with the lower and higher doses of SNa (0.2 and 1 ng/g) respectively exhibited significant 1.77- and 2.58-fold higher food intake (p < 0.0001) than the saline-injected control fish. Locomotor behavior was increased by 1.35- and 2.26-fold for 0.2 ng/g SNa (p = 0.0001) and 1 ng/g SNa (p < 0.0001), respectively. Injection of 1 ng/g SNa increased mRNA levels of hypothalamic neuropeptide Y 1.36-fold (p = 0.038) and decreased hypothalamic cocaine-and amphetamine-regulated transcript by 33% (p = 0.01) at 2 h and 5 h post-injection, respectively. These data suggest interactions of SNa with stimulatory and inhibitory pathways of food intake control in fish. (C) 2016 Elsevier Inc. All rights reserved.
SubtypeArticle
KeywordFeeding Locomotion Secretogranin-ii Secretoneurin Fish
DOI10.1016/j.peptides.2016.01.007
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNSERC-Discovery, uOttawa International Research Acceleration Programs ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; Ministry of Higher Education of Saudi Arabia ; Ministry of Higher Education of Saudi Arabia ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; Ministry of Higher Education of Saudi Arabia ; Ministry of Higher Education of Saudi Arabia
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS KeywordDIFFUSE NEUROENDOCRINE SYSTEM ; NEUROPEPTIDE-Y ; IMMUNOHISTOCHEMICAL LOCALIZATION ; LUTEINIZING-HORMONE ; FEEDING-BEHAVIOR ; OREXIN-A ; PITUITARY ; BRAIN ; EXPRESSION ; IMMUNOREACTIVITY
WOS IDWOS:000372718700006
Funding OrganizationNSERC-Discovery, uOttawa International Research Acceleration Programs ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; Ministry of Higher Education of Saudi Arabia ; Ministry of Higher Education of Saudi Arabia ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; NSERC-Discovery, uOttawa International Research Acceleration Programs ; Ministry of Higher Education of Saudi Arabia ; Ministry of Higher Education of Saudi Arabia
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27935
Collection鱼类生物学及渔业生物技术研究中心
Affiliation1.Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada
2.Mem Univ Newfoundland, Dept Biol, St John, NF, Canada
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Mikwar, M.,Navarro-Martin, L.,Xing, L.,et al. Stimulatory effect of the secretogranin-11 derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)[J]. PEPTIDES,2016,78:42-50.
APA Mikwar, M.,Navarro-Martin, L.,Xing, L.,Volkoff, H.,Hu, W.,&Trudeau, V. L..(2016).Stimulatory effect of the secretogranin-11 derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus).PEPTIDES,78,42-50.
MLA Mikwar, M.,et al."Stimulatory effect of the secretogranin-11 derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)".PEPTIDES 78(2016):42-50.
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