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RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena
Zhao, Xiaolu1,2; Xiong, Jie3; Mao, Fengbiao1; Sheng, Yalan2,4; Chen, Xiao1,2; Feng, Lifang1; Dui, Wen1; Yang, Wentao3; Kapusta, Aurelie5; Feschotte, Cedric6; Coyne, Robert S.7; Miao, Wei3; Gao, Shan2,4; Liu, Yifan1
Corresponding AuthorGao, Shan(shangao@ouc.edu.cn) ; Liu, Yifan(yifan@med.umich.edu)
2019-03-01
Source PublicationGENES & DEVELOPMENT
ISSN0890-9369
Volume33Issue:5-6Pages:348-364
AbstractRNAi and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here, we show that, in the protozoan Tetrahymena thermophila, germline-specific internally eliminated sequences (IESs)-many related to transposable elements (TEs)-become transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Germline TE mobilization also dramatically increases in these mutants. The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and vice versa for transcriptional silencing. The balance between ncRNA and mRNA production is potentially affected by cotranscriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, whose ancestral role is epigenetic silencing of TEs.
KeywordPolycomb repression RNAi transposable elements
DOI10.1101/gad.320796.118
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31301930] ; National Natural Science Foundation of China[31522051] ; National Institutes of Health (NIH)[R01 GM077582] ; National Science Foundation (NSF)[1158346] ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China[2013DFG32390] ; Natural Science Foundation of Shandong Province[JQ201706] ; NIH[R01 GM087343] ; NSF[MCB 1411565] ; Department of Pathology at the University of Michigan
WOS Research AreaCell Biology ; Developmental Biology ; Genetics & Heredity
WOS SubjectCell Biology ; Developmental Biology ; Genetics & Heredity
WOS IDWOS:000460112800009
WOS KeywordPROGRAMMED DNA ELIMINATION ; HISTONE METHYLTRANSFERASE ACTIVITY ; DICER-LIKE PROTEIN ; NONCODING RNA ; GENOME REARRANGEMENT ; NATURAL-HISTORY ; PIRNA CLUSTERS ; METHYLATION ; TRANSCRIPTION ; CHROMATIN
PublisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; National Science Foundation (NSF) ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Projects of International Cooperation and Exchanges Ministry of Science and Technology of China ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; NIH ; NIH ; NIH ; NIH ; NSF ; NSF ; NSF ; NSF ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan ; Department of Pathology at the University of Michigan
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27919
Collection水生生物分子与细胞生物学研究中心
Corresponding AuthorGao, Shan; Liu, Yifan
Affiliation1.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
2.Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266003, Peoples R China
5.Univ Utah, Dept Human Genet, Sch Med, Salt Lake City, UT 84112 USA
6.Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14850 USA
7.J Craig Venter Inst, Rockville, MD 20850 USA
Recommended Citation
GB/T 7714
Zhao, Xiaolu,Xiong, Jie,Mao, Fengbiao,et al. RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena[J]. GENES & DEVELOPMENT,2019,33(5-6):348-364.
APA Zhao, Xiaolu.,Xiong, Jie.,Mao, Fengbiao.,Sheng, Yalan.,Chen, Xiao.,...&Liu, Yifan.(2019).RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena.GENES & DEVELOPMENT,33(5-6),348-364.
MLA Zhao, Xiaolu,et al."RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena".GENES & DEVELOPMENT 33.5-6(2019):348-364.
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